LCRAnnotationsDB: a database of low complexity regions functional and structural annotations

Low Complexity Regions (LCRs) are segments of proteins with a low diversity of amino acid composition. These regions play important roles in proteins. However, annotations describing these functions are dispersed across databases and scientific literature. LCRAnnotationsDB aims to consolidate knowle...

Full description

Saved in:
Bibliographic Details
Published in:BMC genomics 2024-12, Vol.25 (1), p.1251-14, Article 1251
Main Authors: Ziemska-Legiecka, Joanna, Jarnot, Patryk, Szymańska, Sylwia, Błaszczyk, Dagmara, Staśczak, Alicja, Langer-Macioł, Hanna, Lucińska, Kinga, Widzisz, Karolina, Janas, Aleksandra, Słowik, Hanna, Śliwińska, Wiktoria, Gruca, Aleksandra, Grynberg, Marcin
Format: Article
Language:English
Subjects:
Amino acid composition
Amino acids
Annotation
Annotations
Automation
Biological activity
Complexity
Composers
Computational Biology - methods
Databases, Protein
Functionals
Gene Ontology
Humans
Information sources
LCD
LCR
Low complexity regions
Methods
Molecular Sequence Annotation
Ontology
Protein
Protein structure
Proteins
Proteins - chemistry
Proteins - metabolism
Structure-function relationships
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Low Complexity Regions (LCRs) are segments of proteins with a low diversity of amino acid composition. These regions play important roles in proteins. However, annotations describing these functions are dispersed across databases and scientific literature. LCRAnnotationsDB aims to consolidate knowledge about LCRs and store relevant annotations in a single place. To unify redundant annotations, we assigned them categories based on similarity in function, protein structure, and biological process. Categories are organized hierarchically by linking them to Gene Ontology terms. The LCRAnnotationsDB database can be accessed at https://lcrannotdb.lcr-lab.org/ .
ISSN:1471-2164
1471-2164
DOI:10.1186/s12864-024-10960-5