Comparison of tuberculin skin test and QuantiFERON-TB Gold In-Tube test in Bacillus Calmette-Guerin-vaccinated children

Objectives: The aim of this study is to determine the concordance between QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) in children vaccinated with Bacillus Calmette-Guerin (BCG). Methods: This cross-sectional study was done at a pediatric tertiary care center in 33 BCG-vaccin...

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Bibliographic Details
Published in:Lung India 2020-01, Vol.37 (1), p.24-29
Main Authors: Shah, Ira, Kathwate, Jagdish, Shetty, Naman
Format: Article
Language:English
Subjects:
Antigens
BCG
Children
Infections
Laboratories
mantoux test
Medical tests
Original
Patients
Pediatrics
quantiferon
Reading
Skin
Studies
Tuberculin
tuberculin skin test
Tuberculosis
Vaccination
Vaccines
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Summary:Objectives: The aim of this study is to determine the concordance between QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) in children vaccinated with Bacillus Calmette-Guerin (BCG). Methods: This cross-sectional study was done at a pediatric tertiary care center in 33 BCG-vaccinated children aged 6 months-15 years suspected of Mycobacterium tuberculosis infection or in contact with a patient with open tuberculosis (TB). All patients were tested for TST with purified protein derivative-S 5 tuberculin units and QFT-GIT assays. Concordance was evaluated between TST and QFT assay by kappa coefficient (k). Agreement between the tests was classified into categories: poor if k < 0.20, fair (k = 0.21-0.40), moderate (k = 0.41-0.60), good (k = 0.61-0.80), and very good (k = 0.81-1.00). Results: Both the TST and QFT assay were positive in 13 and negative in eight children, respectively, resulting in an agreement of 63% (κ = 0.31). Eight children were
ISSN:0970-2113
0974-598X
DOI:10.4103/lungindia.lungindia_304_19