Phenolic compounds and antimicrobial activity of olive (Olea europaea L. Cv. Cobrançosa) leaves

We report the determination of phenolic compounds in olive leaves by reversed-phase HPLC/DAD, and the evaluation of their in vitro activity against several microorganisms that may be causal agents of human intestinal and respiratory tract infections, namely gram positive (Bacillus cereus, B. subtili...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2007-05, Vol.12 (5), p.1153-1162
Main Authors: Pereira, Ana Paula, Ferreira, Isabel C F R, Marcelino, Filipa, Valentão, Patricia, Andrade, Paula B, Seabra, Rosa, Estevinho, Leticia, Bento, Albino, Pereira, José Alberto
Format: Article
Language:English
Subjects:
Acids
Anti-Infective Agents - isolation & purification
Anti-Infective Agents - pharmacology
Antibacterial activity
Antifungal activity
Antimicrobial agents
Chromatography, High Pressure Liquid
Leaves
Microbial Sensitivity Tests
Molecular Structure
Olea - chemistry
Olive leaves
Phenolic compounds
Phenols - chemistry
Phenols - isolation & purification
Phenols - pharmacology
Plant Leaves - chemistry
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Summary:We report the determination of phenolic compounds in olive leaves by reversed-phase HPLC/DAD, and the evaluation of their in vitro activity against several microorganisms that may be causal agents of human intestinal and respiratory tract infections, namely gram positive (Bacillus cereus, B. subtilis and Staphylococcus aureus), gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae) and fungi (Candida albicans and Cryptococcus neoformans). Seven phenolic compounds were identified and quantified: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-O-glucoside and luteolin 4'-O-glucoside. At low concentrations olive leaves extracts showed an unusual combined antibacterial and antifungal action, which suggest their great potential as nutraceuticals, particularly as a source of phenolic compounds.
ISSN:1420-3049
1420-3049
DOI:10.3390/12051153