Clinical characteristics and risk factors of polymicrobial Staphylococcus aureus bloodstream infections

• Published in: Antimicrobial resistance & infection control 2020-05, Vol.9 (1), p.76-76, Article 76
• Main Authors: Zheng, Cheng, Zhang, Shufang, Chen, Qingqing, Zhong, Li, Huang, Tiancha, Zhang, Xijiang, Zhang, Kai, Zhou, Hongwei, Cai, Jiachang, Du, Linlin, Wang, Changming, Cui, Wei, Zhang, Gensheng
• Format: Article
• Language: English
• Subjects: Adult; Age; Aged; Antibiotics; Bacteremia; Bacteremia - microbiology; Bacteremia - mortality; Blood Transfusion; Blood transfusions; Burns - complications; Burns - microbiology; Case-Control Studies; Comorbidity; Disease control; Drug resistance; Ethics; Health aspects; Hospitals; Humans; Indicator organisms; Infection; Laboratories; Length of Stay; Medical records; Medical research; Medical schools; Microorganisms; Middle Aged; Mortality; Neutropenia; Nosocomial infections; Observational studies; Parenteral nutrition; Pathogens; Patients; Polymicrobial Staphylococcus aureus bloodstream infections; Respiration, Artificial - adverse effects; Retrospective Studies; Risk factors; Sepsis; Staphylococcal Infections - microbiology; Staphylococcal Infections - mortality; Staphylococcus aureus; Staphylococcus aureus infections; Staphylococcus infections; Statistical analysis; Studies; Transfusion; Trauma; Ventilation; Ventilators
• ISSN: 2047-2994; 2047-2994
• DOI: 10.1186/s13756-020-00741-6

Although Staphylococcus aureus bloodstream infections (SA-BSI) are a common and important infection, polymicrobial SA-BSI are infrequently reported. The aim of this study was to investigate the clinical characteristics and risk factors of polymicrobial SA-BSI in comparison with monomicrobial SA-BSI. A single-center retrospective observational study was performed between Jan 1, 2013, and Dec 31, 2018 at a tertiary hospital. All patients with SA-BSI were enrolled, and their clinical data were gathered by reviewing electronic medical records. A total of 349 patients with SA-BSI were enrolled including 54 cases (15.5%) with polymicrobial SA-BSI. In multivariable analysis, burn injury (adjusted odds ratio [OR], 7.04; 95% confidence interval [CI], 1.71-28.94), need of blood transfusion (aOR, 2.72; 95% CI, 1.14-6.50), use of mechanical ventilation (aOR, 3.11; 95% CI, 1.16-8.30), the length of prior hospital stay (aOR, 1.02; 95% CI, 1.00-1.03), and pneumonia as primary site of infection (aOR, 4.22; 95% CI, 1.69-10.51) were independent factors of polymicrobial SA-BSI. In comparison with monomicrobial SA-BSI, patients with polymicrobial SA-BSI had longer length of ICU stay [median days, 23(6.25,49.25) vs. 0(0,12), p