DTI Measurements in Multiple Sclerosis: Evaluation of Brain Damage and Clinical Implications

Diffusion tensor imaging (DTI) is an effective means of quantifying parameters of demyelination and axonal loss. The application of DTI in Multiple Sclerosis (MS) has yielded noteworthy results. DTI abnormalities, which are already detectable in patients with clinically isolated syndrome (CIS), beco...

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Bibliographic Details
Published in:Multiple Sclerosis International 2013-01, Vol.2013 (2013), p.212-222
Main Authors: Sbardella, Emilia, Tona, Francesca, Petsas, Nikolaos, Pantano, Patrizia
Format: Article
Language:English
Subjects:
Analysis
Anisotropy
Diagnosis
Edema
Evaluation
Magnetic resonance imaging
Multiple sclerosis
Pediatrics
Prognosis
Review
Studies
Values
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Summary:Diffusion tensor imaging (DTI) is an effective means of quantifying parameters of demyelination and axonal loss. The application of DTI in Multiple Sclerosis (MS) has yielded noteworthy results. DTI abnormalities, which are already detectable in patients with clinically isolated syndrome (CIS), become more pronounced as disease duration and neurological impairment increase. The assessment of the microstructural alterations of white and grey matter in MS may shed light on mechanisms responsible for irreversible disability accumulation. In this paper, we examine the DTI analysis methods, the results obtained in the various tissues of the central nervous system, and correlations with clinical features and other MRI parameters. The adoption of DTI metrics to assess the outcome of prognostic measures may represent an extremely important step forward in the MS research field.
ISSN:2090-2654
2090-2662
DOI:10.1155/2013/671730