Psychobiotics Regulate the Anxiety Symptoms in Carriers of Allele A of IL-1β Gene: A Randomized, Placebo-Controlled Clinical Trial

Background. Probiotic oral intake, via modulation of the microbiota-gut-brain axis, can impact brain activity, mood, and behavior; therefore, it may be beneficial against psychological distress and anxiety disorders. Inflammatory cytokines can influence the onset and progression of several neurodege...

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Bibliographic Details
Published in:Mediators of inflammation 2020, Vol.2020 (2020), p.1-11
Main Authors: Di Renzo, Laura, Condò, Roberta, Cammarano, A., Romano, L., De Lorenzo, Antonino, Cioccoloni, G., Marchetti, M., Gualtieri, Paola, Colica, Carmen
Format: Article
Language:English
Subjects:
Adult
Alleles
Anxiety - drug therapy
Anxiety - genetics
Anxiety - psychology
Anxiety disorders
Chronic illnesses
Clinical trials
Cytokines
Diabetes
Dietary supplements
Emotional disorders
Family medical history
Female
Gene polymorphism
Genotyping
Heterozygote
Humans
IL-1β
Interleukin-1beta - genetics
Male
Mental depression
Microbiota
Middle Aged
Mood
Mood disorders
Nervous system
Permeability
Phenotypes
Polymorphism
Polymorphism, Single Nucleotide
Probiotics
Probiotics - therapeutic use
Quantitative psychology
Risk factors
Single-nucleotide polymorphism
Studies
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Summary:Background. Probiotic oral intake, via modulation of the microbiota-gut-brain axis, can impact brain activity, mood, and behavior; therefore, it may be beneficial against psychological distress and anxiety disorders. Inflammatory cytokines can influence the onset and progression of several neurodegenerative mood disorders, and the IL-1β rs16944 SNP is related to high cytokine levels and potentially affects mood disorders. The aim of this study was to examine the combined effect of IL-1β polymorphism and probiotic administration in mood disorder phenotypes in the Italian population. Methods. 150 subjects were randomized into two different groups, probiotic oral suspension group (POSG) and placebo control group (PCG), and received the relative treatment for 12 weeks. Psychological profile assessment by Hamilton Anxiety Rating Scale (HAM-A), Body Uneasiness Test (BUT), and Symptom Checklist 90-Revised (SCL90R) was administered to all volunteers. Genotyping was performed on DNA extracted from salivary samples. Results. After 12 weeks of intervention, a significant reduction of HAM-A total score was detected in the POSG (p
ISSN:0962-9351
1466-1861
DOI:10.1155/2020/2346126