Psychobiotics Regulate the Anxiety Symptoms in Carriers of Allele A of IL-1β Gene: A Randomized, Placebo-Controlled Clinical Trial

Background. Probiotic oral intake, via modulation of the microbiota-gut-brain axis, can impact brain activity, mood, and behavior; therefore, it may be beneficial against psychological distress and anxiety disorders. Inflammatory cytokines can influence the onset and progression of several neurodege...

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Published in:Mediators of inflammation 2020, Vol.2020 (2020), p.1-11
Main Authors: Di Renzo, Laura, Condò, Roberta, Cammarano, A., Romano, L., De Lorenzo, Antonino, Cioccoloni, G., Marchetti, M., Gualtieri, Paola, Colica, Carmen
Format: Article
Language:English
Subjects:
Adult
Alleles
Anxiety - drug therapy
Anxiety - genetics
Anxiety - psychology
Anxiety disorders
Chronic illnesses
Clinical trials
Cytokines
Diabetes
Dietary supplements
Emotional disorders
Family medical history
Female
Gene polymorphism
Genotyping
Heterozygote
Humans
IL-1β
Interleukin-1beta - genetics
Male
Mental depression
Microbiota
Middle Aged
Mood
Mood disorders
Nervous system
Permeability
Phenotypes
Polymorphism
Polymorphism, Single Nucleotide
Probiotics
Probiotics - therapeutic use
Quantitative psychology
Risk factors
Single-nucleotide polymorphism
Studies
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cited_by cdi_FETCH-LOGICAL-c537t-adbca1dbb5cb1a0e81c95646761976026c3009c5ed289e35d54f49d34757f7a63
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container_end_page 11
container_issue 2020
container_start_page 1
container_title Mediators of inflammation
container_volume 2020
creator Di Renzo, Laura
Condò, Roberta
Cammarano, A.
Romano, L.
De Lorenzo, Antonino
Cioccoloni, G.
Marchetti, M.
Gualtieri, Paola
Colica, Carmen
description Background. Probiotic oral intake, via modulation of the microbiota-gut-brain axis, can impact brain activity, mood, and behavior; therefore, it may be beneficial against psychological distress and anxiety disorders. Inflammatory cytokines can influence the onset and progression of several neurodegenerative mood disorders, and the IL-1β rs16944 SNP is related to high cytokine levels and potentially affects mood disorders. The aim of this study was to examine the combined effect of IL-1β polymorphism and probiotic administration in mood disorder phenotypes in the Italian population. Methods. 150 subjects were randomized into two different groups, probiotic oral suspension group (POSG) and placebo control group (PCG), and received the relative treatment for 12 weeks. Psychological profile assessment by Hamilton Anxiety Rating Scale (HAM-A), Body Uneasiness Test (BUT), and Symptom Checklist 90-Revised (SCL90R) was administered to all volunteers. Genotyping was performed on DNA extracted from salivary samples. Results. After 12 weeks of intervention, a significant reduction of HAM-A total score was detected in the POSG (p
doi_str_mv 10.1155/2020/2346126
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Probiotic oral intake, via modulation of the microbiota-gut-brain axis, can impact brain activity, mood, and behavior; therefore, it may be beneficial against psychological distress and anxiety disorders. Inflammatory cytokines can influence the onset and progression of several neurodegenerative mood disorders, and the IL-1β rs16944 SNP is related to high cytokine levels and potentially affects mood disorders. The aim of this study was to examine the combined effect of IL-1β polymorphism and probiotic administration in mood disorder phenotypes in the Italian population. Methods. 150 subjects were randomized into two different groups, probiotic oral suspension group (POSG) and placebo control group (PCG), and received the relative treatment for 12 weeks. Psychological profile assessment by Hamilton Anxiety Rating Scale (HAM-A), Body Uneasiness Test (BUT), and Symptom Checklist 90-Revised (SCL90R) was administered to all volunteers. Genotyping was performed on DNA extracted from salivary samples. Results. After 12 weeks of intervention, a significant reduction of HAM-A total score was detected in the POSG (p&lt;0.01), compared to the PCG. Furthermore, IL-1β carriers have moderate risk to develop anxiety (OR=5.90), and in POSG IL-1β carriers, we observed a reduction of HAM-A score (p=0.02). Conclusions. Consumption of probiotics mitigates anxiety symptoms, especially in healthy adults with the minor A allele of rs16944 as a risk factor. Our results encourage the use of probiotics in anxiety disorders and suggest genetic association studies for psychobiotic-personalized therapy.</description><identifier>ISSN: 0962-9351</identifier><identifier>EISSN: 1466-1861</identifier><identifier>DOI: 10.1155/2020/2346126</identifier><identifier>PMID: 32377159</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adult ; Alleles ; Anxiety - drug therapy ; Anxiety - genetics ; Anxiety - psychology ; Anxiety disorders ; Chronic illnesses ; Clinical trials ; Cytokines ; Diabetes ; Dietary supplements ; Emotional disorders ; Family medical history ; Female ; Gene polymorphism ; Genotyping ; Heterozygote ; Humans ; IL-1β ; Interleukin-1beta - genetics ; Male ; Mental depression ; Microbiota ; Middle Aged ; Mood ; Mood disorders ; Nervous system ; Permeability ; Phenotypes ; Polymorphism ; Polymorphism, Single Nucleotide ; Probiotics ; Probiotics - therapeutic use ; Quantitative psychology ; Risk factors ; Single-nucleotide polymorphism ; Studies</subject><ispartof>Mediators of inflammation, 2020, Vol.2020 (2020), p.1-11</ispartof><rights>Copyright © 2020 P. Gualtieri et al.</rights><rights>Copyright © 2020 P. Gualtieri et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 P. 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Probiotic oral intake, via modulation of the microbiota-gut-brain axis, can impact brain activity, mood, and behavior; therefore, it may be beneficial against psychological distress and anxiety disorders. Inflammatory cytokines can influence the onset and progression of several neurodegenerative mood disorders, and the IL-1β rs16944 SNP is related to high cytokine levels and potentially affects mood disorders. The aim of this study was to examine the combined effect of IL-1β polymorphism and probiotic administration in mood disorder phenotypes in the Italian population. Methods. 150 subjects were randomized into two different groups, probiotic oral suspension group (POSG) and placebo control group (PCG), and received the relative treatment for 12 weeks. Psychological profile assessment by Hamilton Anxiety Rating Scale (HAM-A), Body Uneasiness Test (BUT), and Symptom Checklist 90-Revised (SCL90R) was administered to all volunteers. 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Probiotic oral intake, via modulation of the microbiota-gut-brain axis, can impact brain activity, mood, and behavior; therefore, it may be beneficial against psychological distress and anxiety disorders. Inflammatory cytokines can influence the onset and progression of several neurodegenerative mood disorders, and the IL-1β rs16944 SNP is related to high cytokine levels and potentially affects mood disorders. The aim of this study was to examine the combined effect of IL-1β polymorphism and probiotic administration in mood disorder phenotypes in the Italian population. Methods. 150 subjects were randomized into two different groups, probiotic oral suspension group (POSG) and placebo control group (PCG), and received the relative treatment for 12 weeks. Psychological profile assessment by Hamilton Anxiety Rating Scale (HAM-A), Body Uneasiness Test (BUT), and Symptom Checklist 90-Revised (SCL90R) was administered to all volunteers. Genotyping was performed on DNA extracted from salivary samples. Results. After 12 weeks of intervention, a significant reduction of HAM-A total score was detected in the POSG (p&lt;0.01), compared to the PCG. Furthermore, IL-1β carriers have moderate risk to develop anxiety (OR=5.90), and in POSG IL-1β carriers, we observed a reduction of HAM-A score (p=0.02). Conclusions. Consumption of probiotics mitigates anxiety symptoms, especially in healthy adults with the minor A allele of rs16944 as a risk factor. Our results encourage the use of probiotics in anxiety disorders and suggest genetic association studies for psychobiotic-personalized therapy.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32377159</pmid><doi>10.1155/2020/2346126</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-8875-6723</orcidid><orcidid>https://orcid.org/0000-0001-6524-4493</orcidid><orcidid>https://orcid.org/0000-0001-7574-2592</orcidid><orcidid>https://orcid.org/0000-0003-0102-9182</orcidid><orcidid>https://orcid.org/0000-0001-7740-2989</orcidid><orcidid>https://orcid.org/0000-0003-2139-7927</orcidid><orcidid>https://orcid.org/0000-0003-1533-4276</orcidid><orcidid>https://orcid.org/0000-0001-6424-1223</orcidid><oa>free_for_read</oa></addata></record>
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ispartof Mediators of inflammation, 2020, Vol.2020 (2020), p.1-11
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source Wiley Online Library Open Access; Publicly Available Content Database; PubMed Central
subjects Adult
Alleles
Anxiety - drug therapy
Anxiety - genetics
Anxiety - psychology
Anxiety disorders
Chronic illnesses
Clinical trials
Cytokines
Diabetes
Dietary supplements
Emotional disorders
Family medical history
Female
Gene polymorphism
Genotyping
Heterozygote
Humans
IL-1β
Interleukin-1beta - genetics
Male
Mental depression
Microbiota
Middle Aged
Mood
Mood disorders
Nervous system
Permeability
Phenotypes
Polymorphism
Polymorphism, Single Nucleotide
Probiotics
Probiotics - therapeutic use
Quantitative psychology
Risk factors
Single-nucleotide polymorphism
Studies
title Psychobiotics Regulate the Anxiety Symptoms in Carriers of Allele A of IL-1β Gene: A Randomized, Placebo-Controlled Clinical Trial
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