CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study

C-reactive protein (CRP) encoded by CRP gene is a reflection of systemic inflammation. Many studies associated CRP level with diabetes and glucose levels, but the association of CRP gene with these traits is unclear. We conducted a cross-sectional study consisting of 945 siblings from 330 families c...

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Bibliographic Details
Published in:Scientific reports 2017-08, Vol.7 (1), p.7987-8, Article 7987
Main Authors: Sheu, Wayne Huey-Herng, Wang, Wen-Chang, Wu, Kwan-Dun, He, Chih-Tsueng, Hwu, Chii-Min, Quertermous, Thomas, Hsieh, Wan-Shan, Lee, Wen-Jane, Ting, Chih-Tai, Chen, Yii-Der I., Hsiung, Chao A.
Format: Article
Language:English
Subjects:
45
631/208/205
631/208/2489/144
631/208/729
Alleles
C-reactive protein
Diabetes
Diabetes mellitus
Fasting
Gene polymorphism
Glucose
Glucose tolerance
Humanities and Social Sciences
Insulin
Intolerance
Laboratory testing
multidisciplinary
Science
Science (multidisciplinary)
Siblings
Single-nucleotide polymorphism
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Summary:C-reactive protein (CRP) encoded by CRP gene is a reflection of systemic inflammation. Many studies associated CRP level with diabetes and glucose levels, but the association of CRP gene with these traits is unclear. We conducted a cross-sectional study consisting of 945 siblings from 330 families collected by the Stanford Asian Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe) to investigate associations between CRP polymorphisms, circulating CRP, diabetes, and glucose levels. Five single-nucleotide polymorphisms were analyzed: rs3093059, rs2794521, rs1417938, rs1800947, and rs1205. The generalized estimating equation approach was used to deal with correlated data within families. CRP level was positively correlated with diabetes prevalence and levels of fasting and 2-hour glucose (each P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-08696-2