Metformin as Host-Directed Therapy for TB Treatment: Scoping Review

Tuberculosis (TB) disease is an international health concern caused by the bacteria . Evolution of multi-drug-resistant strains may cause bacterial persistence, rendering existing antibiotics ineffective. Hence, development of new or repurposing of currently approved drugs to fight in combination wi...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in microbiology 2020-04, Vol.11, p.435-435
Main Authors: Naicker, Nikita, Sigal, Alex, Naidoo, Kogieleum
Format: Article
Language:English
Subjects:
adjuvant
host-directed therapy
metformin
Microbiology
Mycobacterium tuberculosis
tuberculosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tuberculosis (TB) disease is an international health concern caused by the bacteria . Evolution of multi-drug-resistant strains may cause bacterial persistence, rendering existing antibiotics ineffective. Hence, development of new or repurposing of currently approved drugs to fight in combination with existing antibiotics is urgently needed to cure TB which is refractory to current therapy. The shortening of TB therapy and reduction in lung injury can be achieved using adjunctive host-directed therapies. There is a wide range of probable candidates which include numerous agents permitted for the treatment of other diseases. One potential candidate is metformin, a Food and Drug Administration (FDA)-approved drug used to treat type 2 diabetes mellitus (DM). However, there is a scarcity of evidence supporting the biological basis for the effect of metformin as a host-directed therapy for TB. This scoping review summarizes the current body of evidence and outlines scientific gaps that need to be addressed in determining the potential role of metformin as a host-directed therapy.
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2020.00435