Dietary Prebiotics, Milk Fat Globule Membrane, and Lactoferrin Affects Structural Neurodevelopment in the Young Piglet

Milk fat globule membrane (MFGM) and lactoferrin have been identified as two components that have potential to affect neurodevelopment. While concentrations of some MFGM constituents in infant formulas are within human milk range, they may not be present at optimal or clinically effective levels. Ho...

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Bibliographic Details
Published in:Frontiers in pediatrics 2016-02, Vol.4, p.4-4
Main Authors: Mudd, Austin T, Alexander, Lindsey S, Berding, Kirsten, Waworuntu, Rosaline V, Berg, Brian M, Donovan, Sharon M, Dilger, Ryan N
Format: Article
Language:English
Subjects:
infant nutrition
Internal Capsule
Lactoferrin
neurodevelopment
Pediatrics
pig
Prebiotics
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Summary:Milk fat globule membrane (MFGM) and lactoferrin have been identified as two components that have potential to affect neurodevelopment. While concentrations of some MFGM constituents in infant formulas are within human milk range, they may not be present at optimal or clinically effective levels. However, lactoferrin levels of infant formulas are consistently reported to be lower than human milk. This study sought to provide a novel combination of prebiotics, bovine-derived MFGM, and lactoferrin and assess their influence on neurodevelopment. Twenty-four male piglets were provided either TEST (n = 12) or CONT (n = 12) diet from 2 to 31 days of age. Piglets underwent spatial T-maze assessment starting at 17 days of age, were subjected to magnetic resonance imaging at 30 days of age, and were euthanized for tissue collection at 31 days of age. Diffusion tensor imaging revealed differences in radial (P = 0.032) and mean (P = 0.028) diffusivities in the internal capsule, where CONT piglets had higher rates of diffusion compared with TEST piglets. Voxel-based morphometry indicated larger (P 
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2016.00004