Combined hepatoprotective and antidepressant effects of resveratrol in an acute model of depression

There are numerous herbal medicines that have been introduced into psychiatric practice because of greater compliance and milder side effects. Polygonum cuspidatum is a native Asian plant; known for its medicinal properties and traditionally used in the treatment of neuropsychiatric disorders, such...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of the Faculty of Pharmacy 2014-12, Vol.52 (2), p.191-197
Main Authors: Ahmed, Rania F., Abdel-Rahman, Rehab Fawzy, Farid, Omar A.H.A., El-Marasy, Salma A., Hessin, Alyaa F.
Format: Article
Language:English
Subjects:
Antioxidants
Behavior
Depression
Neurotransmitters
Polygonum cuspidatum
Resveratrol
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There are numerous herbal medicines that have been introduced into psychiatric practice because of greater compliance and milder side effects. Polygonum cuspidatum is a native Asian plant; known for its medicinal properties and traditionally used in the treatment of neuropsychiatric disorders, such as psychosocial stress, dementia and Parkinson’s disease. Resveratrol is the active ingredient of P. cuspidatum. Researchers have suggested that the trans-isomer of resveratrol demonstrates a variety of pharmacological activities including antioxidant, anti-inflammatory, hepatic and neuroprotective properties. In this study we examined the hepatoprotective and antidepressant effects of trans-resveratrol against fluoxetine in an acute reserpine model of depression in rats. Main methods: depression-like behaviors were induced by single reserpine intraperitoneal injection (6mg/kg, i.p.). Trans-resveratrol (15, 30 and 60mg/kgbwt) and fluoxetine (24mg/kgbwt) were administered orally for the following 3days. Behavioral effects namely open field test (OFT) and forced swimming test (FST) and biochemical parameters namely neurotransmitters levels and antioxidant contents were assessed. Liver histopathological examination was performed. Key findings: Results revealed that resveratrol (60mg/kgbwt) showed a potential hepatoprotective and an antidepressant-like effects compared to those of fluoxetine.
ISSN:1110-0931
2090-9101
DOI:10.1016/j.bfopcu.2014.06.002