Electroencephalography in the Diagnosis of Genetic Generalized Epilepsy Syndromes

Genetic generalized epilepsy (GGE) consists of several syndromes diagnosed and classified on the basis of clinical features and electroencephalographic (EEG) abnormalities. The main EEG feature of GGE is bilateral, synchronous, symmetric, and generalized spike-wave complex. Other classic EEG abnorma...

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Bibliographic Details
Published in:Frontiers in neurology 2017-09, Vol.8, p.499-499
Main Authors: Seneviratne, Udaya, Cook, Mark J, D'Souza, Wendyl Jude
Format: Article
Language:English
Subjects:
absence seizure
myoclonic seizure
Neuroscience
photoparoxysmal response
polyspike
sleep
spike-wave
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Summary:Genetic generalized epilepsy (GGE) consists of several syndromes diagnosed and classified on the basis of clinical features and electroencephalographic (EEG) abnormalities. The main EEG feature of GGE is bilateral, synchronous, symmetric, and generalized spike-wave complex. Other classic EEG abnormalities are polyspikes, epileptiform K-complexes and sleep spindles, polyspike-wave discharges, occipital intermittent rhythmic delta activity, eye-closure sensitivity, fixation-off sensitivity, and photoparoxysmal response. However, admixed with typical changes, atypical epileptiform discharges are also commonly seen in GGE. There are circadian variations of generalized epileptiform discharges. Sleep, sleep deprivation, hyperventilation, intermittent photic stimulation, eye closure, and fixation-off are often used as activation techniques to increase the diagnostic yield of EEG recordings. Reflex seizure-related EEG abnormalities can be elicited by the use of triggers such as cognitive tasks and pattern stimulation during the EEG recording in selected patients. Distinct electrographic abnormalities to help classification can be identified among different electroclinical syndromes.
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2017.00499