A Genome-Wide Association Study Identified Novel Genetic Susceptibility Loci for Oral Cancer in Taiwan

Taiwan has the highest incidence rate of oral cancer in the world. Although oral cancer is mostly an environmentally induced cancer, genetic factors also play an important role in its etiology. Genome-wide association studies (GWAS) have identified nine susceptibility regions for oral cancers in pop...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-02, Vol.24 (3), p.2789
Main Authors: Bau, Da-Tian, Liu, Ting-Yuan, Tsai, Chia-Wen, Chang, Wen-Shin, Gu, Jian, Yang, Jai-Sing, Shih, Liang-Chun, Tsai, Fuu-Jen
Format: Article
Language:English
Subjects:
Alcohol
Alcohol dehydrogenase
Antigens
Carcinogenesis
Carcinogens
Case-Control Studies
Chromosome 15
Chromosome 4
Chromosome 5
Chromosome 6
Chromosome 8
Chromosome 9
Chromosomes
Dehydrogenases
Etiology
Genes
Genetic factors
Genetic Loci
Genetic Predisposition to Disease
Genome-wide association studies
Genome-Wide Association Study
Genomes
Head & neck cancer
Histocompatibility antigen HLA
Histocompatibility Antigens Class I
HLA
Humans
Laminin
Mouth Neoplasms - genetics
Oral cancer
Peptides
Polymorphism, Single Nucleotide
Population
Populations
SNP
Taiwan
TERT
TPRS1
Vesicular Transport Proteins
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Summary:Taiwan has the highest incidence rate of oral cancer in the world. Although oral cancer is mostly an environmentally induced cancer, genetic factors also play an important role in its etiology. Genome-wide association studies (GWAS) have identified nine susceptibility regions for oral cancers in populations of European descent. In this study, we performed the first GWAS of oral cancer in Taiwan with 1529 cases and 44,572 controls. We confirmed two previously reported loci on the 6p21.33 (HLA-B) and 6p21.32 (HLA-DQ gene cluster) loci, highlighting the importance of the human leukocyte antigen and, hence, the immunologic mechanisms in oral carcinogenesis. The TERT-CLMPT1L locus on 5p15.33, the 4q23 ADH1B locus, and the LAMC3 locus on 9q34.12 were also consistent in the Taiwanese. We found two new independent loci on 6p21.32, rs401775 in SKIV2L gene and rs9267798 in TNXB gene. We also found two suggestive novel Taiwanese-specific loci near the TPRS1 gene on 8q23.3 and in the TMED3 gene on 15q25.1. This study identified both common and unique oral cancer susceptibility loci in the Taiwanese as compared to populations of European descent and shed significant light on the etiology of oral cancer in Taiwan.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24032789