Wrinkle Reduction Using Tetrapeptide-68 Contained in an O/W Formulation: A Randomized Double-Blind Placebo-Controlled Study

Peptides, composed of 2-50 amino acids, have gained attention in anti-aging treatments due to their high safety, low irritation, and cost-effective production. This study aimed to evaluate the anti-wrinkle efficacy of Tetrapeptide-68, derived from the skin structural protein Loricrin, on periorbital...

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Bibliographic Details
Published in:Pharmaceutics 2024-07, Vol.16 (8), p.987
Main Authors: Lee, Sung-Gyu, Kang, Sang-Moon, Kang, Hyun
Format: Article
Language:English
Subjects:
Aging
Amino acids
anti-aging
anti-wrinkle
Apoptosis
clinical trial
Collagen
Cosmetics
Hydrogenation
peptide
Peptides
Pharmaceuticals
Physiology
Proteins
Skin diseases
Tetrapeptide-68 cream
Wound healing
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Summary:Peptides, composed of 2-50 amino acids, have gained attention in anti-aging treatments due to their high safety, low irritation, and cost-effective production. This study aimed to evaluate the anti-wrinkle efficacy of Tetrapeptide-68, derived from the skin structural protein Loricrin, on periorbital wrinkles in women aged 30-65 years. A 12-week, double-blind, randomized controlled trial was conducted with 25 participants who applied the Tetrapeptide-68 (100 ppm) O/W formulation around the eyes. Skin physiological parameters were assessed at baseline, 4, 8, and 12 weeks. Participants also completed efficacy and usability questionnaires. Significant improvements in wrinkle reduction were observed with Tetrapeptide-68 cream treatment, as measured by various skin roughness parameters and 3D imaging analysis. Participants reported positive changes in skin texture and moisture levels, with no adverse reactions noted. Tetrapeptide-68 cream demonstrates promising anti-wrinkle effects, highlighting its potential as an effective ingredient in anti-aging skincare formulations. Further studies are recommended to explore its long-term benefits and underlying mechanisms.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics16080987