TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies

The TGF-β signaling pathway plays a crucial role in several key aspects of development and tissue homeostasis. TGF-β ligands and their mediators have been shown to be important regulators of ocular physiology and their dysregulation has been described in several eye pathologies. TGF-β signaling part...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2022-07, Vol.11 (15), p.2336
Main Authors: Hachana, Soumaya, Larrivée, Bruno
Format: Article
Language:English
Subjects:
age-related macular degeneration
Angiogenesis
Binding sites
BMP
Cornea
Cytokines
Diabetes mellitus
Eye diseases
Fibrosis
Glaucoma
Homeostasis
Inflammation
Kinases
Ligands
Macular degeneration
Mammals
Neurogenesis
ocular diseases
Phosphorylation
Proteins
Regulation
Retinopathy
Review
Roles
Signal transduction
TGF-β
Transforming growth factor-b
Vascularization
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Summary:The TGF-β signaling pathway plays a crucial role in several key aspects of development and tissue homeostasis. TGF-β ligands and their mediators have been shown to be important regulators of ocular physiology and their dysregulation has been described in several eye pathologies. TGF-β signaling participates in regulating several key developmental processes in the eye, including angiogenesis and neurogenesis. Inadequate TGF-β signaling has been associated with defective angiogenesis, vascular barrier function, unfavorable inflammatory responses, and tissue fibrosis. In addition, experimental models of corneal neovascularization, diabetic retinopathy, proliferative vitreoretinopathy, glaucoma, or corneal injury suggest that aberrant TGF-β signaling may contribute to the pathological features of these conditions, showing the potential of modulating TGF-β signaling to treat eye diseases. This review highlights the key roles of TGF-β family members in ocular physiology and in eye diseases, and reviews approaches targeting the TGF-β signaling as potential treatment options.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells11152336