The effect of neutrophil extracellular traps in venous thrombosis

Neutrophil extracellular traps (NETs) as special release products of neutrophils have received extensive attention. They are composed of decondensed chromatin and coated with nucleoproteins, including histones and some granulosa proteins. NETs can form a network structure to effectively capture and...

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Bibliographic Details
Published in:Thrombosis journal 2023-06, Vol.21 (1), p.67-67, Article 67
Main Authors: Li, Weiwei, Wang, Zixiang, Su, Chen'guang, Liao, Zheng, Pei, Yinxuan, Wang, Jianli, Li, Zixin, Fu, Shijie, Liu, Jinlong
Format: Article
Language:English
Subjects:
Bacteria
Blood clots
Cell cycle
Chromatin
COVID-19
Cytokine storm
DNA binding proteins
Gastric cancer
Health aspects
Histones
Humans
Inflammation
Kinases
Mitochondrial DNA
Neutrophil
Neutrophil extracellular traps
Neutrophils
Proteins
Review
Sepsis
Thrombophlebitis
Thrombosis
Venous thrombosis
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Summary:Neutrophil extracellular traps (NETs) as special release products of neutrophils have received extensive attention. They are composed of decondensed chromatin and coated with nucleoproteins, including histones and some granulosa proteins. NETs can form a network structure to effectively capture and eliminate pathogens and prevent their spread. Not only that, recent studies have shown that NETs also play an important role in venous thrombosis. This review provides the most important updated evidence regarding the mechanism of NETs formation and the role of NETs in the process of venous thrombosis. The potential prophylactic and therapeutic value of NETs in venous thrombotic disease will also be discussed.
ISSN:1477-9560
1477-9560
DOI:10.1186/s12959-023-00512-4