Bronchiolar adenoma/ciliated muconodular papillary tumor mixed with adenocarcinoma in situ in the same tumor

Bronchiolar adenoma (BA)/ciliated muconodular papillary tumor (CMPT) is defined as a benign tumor composed of epithelial and basal cells. Recently, some cases with driver mutations or malignant transformation have been observed. Thus, whether BA/CMPT is benign or malignant remains controversial. We...

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Bibliographic Details
Published in:Thoracic cancer 2023-02, Vol.14 (4), p.427-431
Main Authors: Uchiyama, Suiha, Mizutani, Kenichi, Suzuki, Eriko, Yoshii, Naoko, Watanabe, Takuya, Tsuchida, Hiroyuki, Yobita, Shogo, Iguchi, Kensuke, Nakamura, Minori, Endo, Takumi, Takahashi, Seishiro, Ogawa, Hiroshi, Tanahashi, Masayuki
Format: Article
Language:English
Subjects:
adenocarcinoma in situ
Adenocarcinoma in Situ - genetics
Adenocarcinoma in Situ - surgery
Adenoma - genetics
Aged
bronchiolar adenoma
Cancer
Carcinoma, Papillary - genetics
Carcinoma, Papillary - pathology
Carcinoma, Papillary - surgery
Case Report
Case Reports
ciliated muconodular papillary tumor
Female
Humans
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Mutation
Tomography
Tumors
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Summary:Bronchiolar adenoma (BA)/ciliated muconodular papillary tumor (CMPT) is defined as a benign tumor composed of epithelial and basal cells. Recently, some cases with driver mutations or malignant transformation have been observed. Thus, whether BA/CMPT is benign or malignant remains controversial. We herein report an extremely rare case of a 68‐year‐old woman with a CMPT accompanied by adenocarcinoma in situ (AIS). BA/CMPT existed inside the AIS. The BA/CMPT component did not show any driver mutations; however, the AIS component had an EGFR driver mutation in exon 19. The accumulation of cases and further studies are needed to discuss the malignant potential of BA/CMPT. We report an extremely rare case involving mixed BA/CMPT and AIS in the same tumor. In our case, the AIS component had an EGFR driver mutation in exon 19. No driver mutations were detected in the BA/CMPT component. The tumor boundaries between BA/CMPT and AIS were relatively clear. Driver mutations or malignant transformation in BA/CMPT have been reported in several cases, but the present case, it is thought that the two tumors were incidentally mixed. The malignant potential of BA/CMPT should also be considered.
ISSN:1759-7706
1759-7714
DOI:10.1111/1759-7714.14784