Dynamic Effects of the Third Generation Bisphosphonate of Risedronate on Rat Osteoporotic Fractures for Clinical Usage Guidance

• Published in: Orthopaedic surgery 2021-12, Vol.13 (8), p.2433-2441
• Main Authors: Ke, Cheng‐hui, Li, Hong‐yun, Yang, Dan, Ying, Hao, Xu, Jun, Wang, Jian, Zhu, Hong‐wen, Wang, Lin
• Format: Article
• Language: English
• Subjects: Apoptosis; Biomechanics; Bisphosphonates; Body fat; Bone density; Bone mineral content (BMC); Bone mineral density (BMD); Bones; Drugs; Experiments; Fractures; Lead; Oophorectomy; Osteoporosis; Ovaries; Prevention; Primary osteoporotic fracture (p‐OPF); Risedronate (RD); Skin
• ISSN: 1757-7853; 1757-7861
• DOI: 10.1111/os.13158

Objective To better understand the risks of bisphosphonates in order to develop guidance for appropriate clinical usage, to compared femoral fracture healing at different time points and to explore the effects of Residronate on fracture healing. Methods Osteoporosis model was achieved by ovariectomy surgery, followed by surgical incision of left femoral shaft 4 weeks after ovariectomy surgery. Three days after fracture surgery, risedronateor saline was fed by intragastric administration. X ray examination was used to check the callus formation, Bone Mineral Density (BMD), Bone Mineral Content (BMC), biomechanical, imaging and micromorphological of bone tissue as well as the trabecular bone parameters were all examined. The femoral pathology tissue of each rat was used to analyze trabecular bone parameters, including trabecular bone volume/tissue volume (Tb. BV/TV), bone surface to tissue volume ratio (BS/TV), trabecular bone mineral density (Tb. BMD), trabecular bone number (Tb. N), trabecular bone thickness (Tb. Th) and small bone Trabecular bone space (Tb. Sp). Results Via X‐ray and pathologically, risedronate treatment promoted the callus forming at the fracture site during the following 6 weeks after osteoporotic fracture by X‐ray (P