Corticosteroids, Plasmapheresis, Argatroban, Rituximab, and Sirolimus Provided Clinical Benefit for Catastrophic Antiphospholipid Syndrome in a Patient with a History of Heparin-Induced Thrombocytopenia

We report a patient with catastrophic antiphospholipid syndrome who had significant improvement after corticosteroids, plasmapheresis, argatroban, rituximab, and sirolimus. Argatroban was used instead of heparin due to a history of heparin-induced thrombocytopenia.

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Bibliographic Details
Published in:Case reports in rheumatology 2023-02, Vol.2023, p.1-5
Main Authors: Hasan, Haytham, Surjancev, Ivana, Arnason, Jon A., Garg, Shivani, Rose, William Nicholas
Format: Article
Language:English
Subjects:
Antibodies
Anticoagulants
Antimitotic agents
Antineoplastic agents
Antiphospholipid syndrome
Apheresis
Argatroban
Autoimmune diseases
B cells
Biopsy
Blood platelets
Case Report
Case reports
Corticosteroids
Development and progression
Diabetes
Evidence-based medicine
Fondaparinux
Glycoproteins
Hematology
Immunotherapy
Monoclonal antibodies
Pain
Patients
Plasma exchange (Therapeutics)
Rapamycin
Skin
Steroids
Thrombocytopenia
Thrombosis
Tomography
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Description
Summary:We report a patient with catastrophic antiphospholipid syndrome who had significant improvement after corticosteroids, plasmapheresis, argatroban, rituximab, and sirolimus. Argatroban was used instead of heparin due to a history of heparin-induced thrombocytopenia.
ISSN:2090-6889
2090-6897
DOI:10.1155/2023/3226278