Clinical significance of albumin to globulin ratio among patients with stroke-associated pneumonia

• Published in: Frontiers in nutrition (Lausanne) 2022-08, Vol.9, p.970573-970573
• Main Authors: Chen, Lingli, Xu, Minjie, Huang, Qiqi, Liu, Yuntao, Ren, Wenwei
• Format: Article
• Language: English
• Subjects: acute ischemic stroke; albumin to globulin; Nutrition; pneumonia; predict; ratio; risk
• ISSN: 2296-861X; 2296-861X
• DOI: 10.3389/fnut.2022.970573

BackgroundIt has been proven that the ratio of albumin to globulin (A/G) is a typical biomarker for monitoring inflammation and nutritional status. But the potential role of A/G in stroke-associated pneumonia (SAP) after acute ischemic stroke (AIS) remained unknown. Patients and methodsFollowing inclusion criteria, 5,173 AIS patients were included and segmented into SAP (n = 897) and non-SAP (n = 4,276) groups. The differences in variables between groups were compared. The logistic regression model was used to determine the association between A/G and SAP, and a forest plot was drawn. ResultsCompared with the non-SAP group, the SAP group had a lower A/G level (P < 0.001). Then, A/G was divided into quartiles. In comparison to Q3 (A/G = 1.25-1.39), logistic regression revealed that patients with a lower A/G (A/G ≤ 1.09) had a higher risk of SAP (OR = 1.96, 95% CI, 1.56-2.46, P < 0.001). On the contrary, those with a higher A/G (A/G ≥ 1.4) had a lower SAP risk (OR = 0.73, 95% CI, 0.54-0.97, P = 0.029). ConclusionThe study revealed that a low A/G level was associated with an increased SAP risk. Appropriate preventative measures for SAP should be taken in AIS patients with a low A/G level.