Diagnostic significance of CD10 marker to differentiate colorectal adenocarcinoma from adenomatous polyp: A pathological correlation

Colorectal cancer could be developed from adenomatous polyp. The study aimed to evaluate the diagnostic significance of stromal and epithelial CD10 (Neprilysin) expression in patients with colorectal adenocarcinoma and adenomatous polyps. This cross-sectional study was conducted on 141 patients with...

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Bibliographic Details
Published in:Caspian journal of internal medicine 2024-01, Vol.15 (2), p.228-233
Main Authors: Dehini, Ghasem, Ghorbani, Hossein, Khafri, Soraya, Shokri Shirvani, Javad, Hosseini, Akramossadat, Sadr Mohararpur, Sahar, Rouhi, Tina
Format: Article
Language:English
Subjects:
adenomatous polyps
colorectal neoplasms
immunohistochemistry
neprilysin
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Summary:Colorectal cancer could be developed from adenomatous polyp. The study aimed to evaluate the diagnostic significance of stromal and epithelial CD10 (Neprilysin) expression in patients with colorectal adenocarcinoma and adenomatous polyps. This cross-sectional study was conducted on 141 patients with colorectal adenocarcinoma and adenomatous polyps referred to Ayatollah Rouhani Hospital from March 2020 to March 2021. Differential diagnoses of colorectal adenocarcinoma and adenomatous polyps were made colonoscopically, and then samples were taken from the lesions. The pathologists confirmed the final diagnosis as colorectal adenocarcinoma, high-grade or low-grade adenomatous polyps. The stromal and epithelial CD10 expression was evaluated by immunohistochemistry. The data was analyzed by SPSS 22 software (p
ISSN:2008-6164
2008-6172
DOI:10.22088/cjim.15.2.228