In vivo Hepatoprotective and in vitro Radical Scavenging Activities of Extracts of Rumex abyssinicus Jacq. Rhizome

Liver diseases contribute a prominent global burden of mortality and morbidity. The current therapies of liver diseases have numerous limitations including severe adverse effects. This denotes that new more effective, safer, and cheaper drugs are required and medicinal plants used in traditional med...

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Bibliographic Details
Published in:Journal of experimental pharmacology 2020, Vol.12, p.221-231
Main Authors: Adamu, Betelhem Anteneh, Emiru, Yohannes Kelifa, Sintayehu, Biruk, Araya, Ephrem Mebrhatu, Periasamy, Gomathi, Gebrelibanos Hiben, Mebrahtom
Format: Article
Language:English
Subjects:
Albinism
Analysis
Animals
Antioxidants
Biphenyl (Compound)
Carbon tetrachloride
Chemicals
Drug dosages
Enzymes
Free radicals
Health aspects
Hepatitis
hepatoprotective
Herbal medicine
Histochemistry
Hospitals
Laboratories
Liver
liver disease
Liver diseases
Medicinal plants
Mortality
Natural products
Original Research
Oxidative stress
rumex abyssinicus
Toxicity
Tropical diseases
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Summary:Liver diseases contribute a prominent global burden of mortality and morbidity. The current therapies of liver diseases have numerous limitations including severe adverse effects. This denotes that new more effective, safer, and cheaper drugs are required and medicinal plants used in traditional medicines often offer ideal opportunities. Accordingly, the present study aimed to evaluate the in vivo hepatoprotective and in vitro radical scavenging activities of dried rhizome extracts of ( ), which is traditionally claimed to provide hepatoprotection. Hepatoprotective activity of extracts was evaluated using carbon tetrachloride (CCl )-induced liver injury in mice. Pre- and post-treatment models were employed to test the effect of the extracts and silymarin (standard drug). Serum biochemical markers and liver histopathology were used as parameters to evaluate hepatoprotective activities whereas in vitro radical scavenging activity was tested by 2, 2-diphenyl-2-picrylhydrazyl hydrate (DPPH) assay. Oral administration of CCl (1 ml/kg) significantly (
ISSN:1179-1454
1179-1454
DOI:10.2147/JEP.S258566