Increased cancer risk after myocardial infarction: fact or fiction? A systemic review and meta-analysis

Accumulating evidences showed some positive relations between myocardial infarction (MI) and new onset cancer. We aim to investigate whether MI is associated with an increased risk of incident cancer. A comprehensive literature list was identified from MEDLINE, Embase, and Web of Science databases f...

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Bibliographic Details
Published in:Cancer management and research 2019-03, Vol.11, p.1959-1968
Main Authors: Li, Na, Huang, Zhigang, Zhang, Yanda, Sun, Haitao, Wang, Jiamei, Zhao, Jian
Format: Article
Language:English
Subjects:
Cancer
Cardiac patients
Health aspects
Heart attack
incident cancer
Lung cancer
meta-analysis
myocardial infarction
Oncology, Experimental
Online databases
Original Research
Risk factors
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Summary:Accumulating evidences showed some positive relations between myocardial infarction (MI) and new onset cancer. We aim to investigate whether MI is associated with an increased risk of incident cancer. A comprehensive literature list was identified from MEDLINE, Embase, and Web of Science databases from inception until October 2018. The main inclusion criteria included observational studies investigating the association between MI and new onset cancer. Stata 12.0 software was used for meta-analysis. Of 862 potentially relevant studies, five cohort studies met all inclusion criteria. The pooled cancer incidence rate was 9.5% (95% CI=8.3-10.7%). Pooled analysis of OR showed that the increased overall cancer risk in MI patients in comparison with controls had no statistical significance (OR=1.08; 95% CI=0.97-1.19, 0.153). Subgroup analysis by gender demonstrated that the overall cancer risk was only significantly increased in female (OR=1.10; 95% CI=1.01-1.20, 0.025), but not in male patients (OR=1.04; 95% CI=0.99-1.10, =0.124). In terms of cancer type, the increased cancer risk was only significant for lung cancer (male OR=1.12; 95% CI=1.05-1.19,
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S193658