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Increased cancer risk after myocardial infarction: fact or fiction? A systemic review and meta-analysis
Accumulating evidences showed some positive relations between myocardial infarction (MI) and new onset cancer. We aim to investigate whether MI is associated with an increased risk of incident cancer. A comprehensive literature list was identified from MEDLINE, Embase, and Web of Science databases f...
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| Published in: | Cancer management and research 2019-03, Vol.11, p.1959-1968 |
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| Main Authors: | , , , , , |
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| Language: | English |
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| container_end_page | 1968 |
| container_issue | |
| container_start_page | 1959 |
| container_title | Cancer management and research |
| container_volume | 11 |
| creator | Li, Na Huang, Zhigang Zhang, Yanda Sun, Haitao Wang, Jiamei Zhao, Jian |
| description | Accumulating evidences showed some positive relations between myocardial infarction (MI) and new onset cancer. We aim to investigate whether MI is associated with an increased risk of incident cancer.
A comprehensive literature list was identified from MEDLINE, Embase, and Web of Science databases from inception until October 2018. The main inclusion criteria included observational studies investigating the association between MI and new onset cancer. Stata 12.0 software was used for meta-analysis.
Of 862 potentially relevant studies, five cohort studies met all inclusion criteria. The pooled cancer incidence rate was 9.5% (95% CI=8.3-10.7%). Pooled analysis of OR showed that the increased overall cancer risk in MI patients in comparison with controls had no statistical significance (OR=1.08; 95% CI=0.97-1.19,
0.153). Subgroup analysis by gender demonstrated that the overall cancer risk was only significantly increased in female (OR=1.10; 95% CI=1.01-1.20,
0.025), but not in male patients (OR=1.04; 95% CI=0.99-1.10,
=0.124). In terms of cancer type, the increased cancer risk was only significant for lung cancer (male OR=1.12; 95% CI=1.05-1.19, |
| doi_str_mv | 10.2147/CMAR.S193658 |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_f49fadeb1c464952b70f39abd119f01c</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A681326056</galeid><doaj_id>oai_doaj_org_article_f49fadeb1c464952b70f39abd119f01c</doaj_id><sourcerecordid>A681326056</sourcerecordid><originalsourceid>FETCH-LOGICAL-c447t-f91889ad5572de166590a5739c8c2ab8ce81c5b06612787898cb70abe9ca96c13</originalsourceid><addsrcrecordid>eNptksuLFDEQxhtR3IfePEvAi4ftMdWPdOJBGQYfAyuCj3Oork7GrN2d3aRnZf570zvjsgOSQ4rKVz8qVV-WvQC-KKBq3qy-LL8tvoMqRS0fZacAjcqhLIrHD-KT7CzGK86FgrJ6mp2UXEqAAk6zzXqkYDCajhGOZAILLv5maKcUDjtPGDqHPXOjxUCT8-NbZpEm5gOz7i7xni1Z3MXJDI5YMLfO_GE4dmwwE-Y4Yr-LLj7Lnljso3l-uM-znx8__Fh9zi-_flqvlpc5VVUz5VaBlAq7um6KzoAQteJYN6UiSQW2kowEqlsuBBSNbKSS1DYcW6MIlSAoz7P1ntt5vNLXwQ0Ydtqj03cJHzYaw-SoN9pWymJnWqBKVKouEsiWCtsOQFkOlFjv9qzrbTuYjsw4BeyPoMcvo_ulN_5Wi4oXVSkS4PUBEPzN1sRJDy6S6Xscjd9GXcxbA8nLOklf7aUbTK2laftEpFmul0KmHQpez8DFf1TpdPPw_WisS_mjgot9AQUfYzD2vnvgeraPnu2jD_ZJ8pcPf3wv_ueX8i9tCMAS</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2193618035</pqid></control><display><type>article</type><title>Increased cancer risk after myocardial infarction: fact or fiction? A systemic review and meta-analysis</title><source>Publicly Available Content Database</source><source>Taylor & Francis Open Access Journals</source><source>PubMed Central</source><creator>Li, Na ; Huang, Zhigang ; Zhang, Yanda ; Sun, Haitao ; Wang, Jiamei ; Zhao, Jian</creator><creatorcontrib>Li, Na ; Huang, Zhigang ; Zhang, Yanda ; Sun, Haitao ; Wang, Jiamei ; Zhao, Jian</creatorcontrib><description>Accumulating evidences showed some positive relations between myocardial infarction (MI) and new onset cancer. We aim to investigate whether MI is associated with an increased risk of incident cancer.
A comprehensive literature list was identified from MEDLINE, Embase, and Web of Science databases from inception until October 2018. The main inclusion criteria included observational studies investigating the association between MI and new onset cancer. Stata 12.0 software was used for meta-analysis.
Of 862 potentially relevant studies, five cohort studies met all inclusion criteria. The pooled cancer incidence rate was 9.5% (95% CI=8.3-10.7%). Pooled analysis of OR showed that the increased overall cancer risk in MI patients in comparison with controls had no statistical significance (OR=1.08; 95% CI=0.97-1.19,
0.153). Subgroup analysis by gender demonstrated that the overall cancer risk was only significantly increased in female (OR=1.10; 95% CI=1.01-1.20,
0.025), but not in male patients (OR=1.04; 95% CI=0.99-1.10,
=0.124). In terms of cancer type, the increased cancer risk was only significant for lung cancer (male OR=1.12; 95% CI=1.05-1.19,
<0.01; and female OR=1.51; 95% CI=1.15-1.99,
<0.01), but not for prostate (OR=0.96; 95% CI=0.85-1.09,
0.546) or breast cancer (OR=0.94; 95% CI=0.86-1.04,
0.222). In addition, the increased cancer risk was only significant in the first 6 months (OR=1.93; 95% CI=1.42-2.63,
<0.01) but not in 6 months-1-year (OR=1.03; 95% CI=0.92-1.15,
0.627) or >1-year (OR=0.98; 95% CI=0.93-1.04,
=0.585) follow-up after MI.
From available evidence, the increased overall cancer risk after MI was only significant in female but not in male patients. Besides, the increased cancer risk could be driven by increased short-term cancer incidence after MI and certain cancer types such as lung cancer.</description><identifier>ISSN: 1179-1322</identifier><identifier>EISSN: 1179-1322</identifier><identifier>DOI: 10.2147/CMAR.S193658</identifier><identifier>PMID: 30881121</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Cancer ; Cardiac patients ; Health aspects ; Heart attack ; incident cancer ; Lung cancer ; meta-analysis ; myocardial infarction ; Oncology, Experimental ; Online databases ; Original Research ; Risk factors</subject><ispartof>Cancer management and research, 2019-03, Vol.11, p.1959-1968</ispartof><rights>COPYRIGHT 2019 Dove Medical Press Limited</rights><rights>2019 Li et al. This work is published and licensed by Dove Medical Press Limited 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-f91889ad5572de166590a5739c8c2ab8ce81c5b06612787898cb70abe9ca96c13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402436/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402436/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,36994,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30881121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Na</creatorcontrib><creatorcontrib>Huang, Zhigang</creatorcontrib><creatorcontrib>Zhang, Yanda</creatorcontrib><creatorcontrib>Sun, Haitao</creatorcontrib><creatorcontrib>Wang, Jiamei</creatorcontrib><creatorcontrib>Zhao, Jian</creatorcontrib><title>Increased cancer risk after myocardial infarction: fact or fiction? A systemic review and meta-analysis</title><title>Cancer management and research</title><addtitle>Cancer Manag Res</addtitle><description>Accumulating evidences showed some positive relations between myocardial infarction (MI) and new onset cancer. We aim to investigate whether MI is associated with an increased risk of incident cancer.
A comprehensive literature list was identified from MEDLINE, Embase, and Web of Science databases from inception until October 2018. The main inclusion criteria included observational studies investigating the association between MI and new onset cancer. Stata 12.0 software was used for meta-analysis.
Of 862 potentially relevant studies, five cohort studies met all inclusion criteria. The pooled cancer incidence rate was 9.5% (95% CI=8.3-10.7%). Pooled analysis of OR showed that the increased overall cancer risk in MI patients in comparison with controls had no statistical significance (OR=1.08; 95% CI=0.97-1.19,
0.153). Subgroup analysis by gender demonstrated that the overall cancer risk was only significantly increased in female (OR=1.10; 95% CI=1.01-1.20,
0.025), but not in male patients (OR=1.04; 95% CI=0.99-1.10,
=0.124). In terms of cancer type, the increased cancer risk was only significant for lung cancer (male OR=1.12; 95% CI=1.05-1.19,
<0.01; and female OR=1.51; 95% CI=1.15-1.99,
<0.01), but not for prostate (OR=0.96; 95% CI=0.85-1.09,
0.546) or breast cancer (OR=0.94; 95% CI=0.86-1.04,
0.222). In addition, the increased cancer risk was only significant in the first 6 months (OR=1.93; 95% CI=1.42-2.63,
<0.01) but not in 6 months-1-year (OR=1.03; 95% CI=0.92-1.15,
0.627) or >1-year (OR=0.98; 95% CI=0.93-1.04,
=0.585) follow-up after MI.
From available evidence, the increased overall cancer risk after MI was only significant in female but not in male patients. Besides, the increased cancer risk could be driven by increased short-term cancer incidence after MI and certain cancer types such as lung cancer.</description><subject>Cancer</subject><subject>Cardiac patients</subject><subject>Health aspects</subject><subject>Heart attack</subject><subject>incident cancer</subject><subject>Lung cancer</subject><subject>meta-analysis</subject><subject>myocardial infarction</subject><subject>Oncology, Experimental</subject><subject>Online databases</subject><subject>Original Research</subject><subject>Risk factors</subject><issn>1179-1322</issn><issn>1179-1322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptksuLFDEQxhtR3IfePEvAi4ftMdWPdOJBGQYfAyuCj3Oork7GrN2d3aRnZf570zvjsgOSQ4rKVz8qVV-WvQC-KKBq3qy-LL8tvoMqRS0fZacAjcqhLIrHD-KT7CzGK86FgrJ6mp2UXEqAAk6zzXqkYDCajhGOZAILLv5maKcUDjtPGDqHPXOjxUCT8-NbZpEm5gOz7i7xni1Z3MXJDI5YMLfO_GE4dmwwE-Y4Yr-LLj7Lnljso3l-uM-znx8__Fh9zi-_flqvlpc5VVUz5VaBlAq7um6KzoAQteJYN6UiSQW2kowEqlsuBBSNbKSS1DYcW6MIlSAoz7P1ntt5vNLXwQ0Ydtqj03cJHzYaw-SoN9pWymJnWqBKVKouEsiWCtsOQFkOlFjv9qzrbTuYjsw4BeyPoMcvo_ulN_5Wi4oXVSkS4PUBEPzN1sRJDy6S6Xscjd9GXcxbA8nLOklf7aUbTK2laftEpFmul0KmHQpez8DFf1TpdPPw_WisS_mjgot9AQUfYzD2vnvgeraPnu2jD_ZJ8pcPf3wv_ueX8i9tCMAS</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Li, Na</creator><creator>Huang, Zhigang</creator><creator>Zhang, Yanda</creator><creator>Sun, Haitao</creator><creator>Wang, Jiamei</creator><creator>Zhao, Jian</creator><general>Dove Medical Press Limited</general><general>Dove Medical Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20190301</creationdate><title>Increased cancer risk after myocardial infarction: fact or fiction? A systemic review and meta-analysis</title><author>Li, Na ; Huang, Zhigang ; Zhang, Yanda ; Sun, Haitao ; Wang, Jiamei ; Zhao, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-f91889ad5572de166590a5739c8c2ab8ce81c5b06612787898cb70abe9ca96c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cancer</topic><topic>Cardiac patients</topic><topic>Health aspects</topic><topic>Heart attack</topic><topic>incident cancer</topic><topic>Lung cancer</topic><topic>meta-analysis</topic><topic>myocardial infarction</topic><topic>Oncology, Experimental</topic><topic>Online databases</topic><topic>Original Research</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Na</creatorcontrib><creatorcontrib>Huang, Zhigang</creatorcontrib><creatorcontrib>Zhang, Yanda</creatorcontrib><creatorcontrib>Sun, Haitao</creatorcontrib><creatorcontrib>Wang, Jiamei</creatorcontrib><creatorcontrib>Zhao, Jian</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Cancer management and research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Na</au><au>Huang, Zhigang</au><au>Zhang, Yanda</au><au>Sun, Haitao</au><au>Wang, Jiamei</au><au>Zhao, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased cancer risk after myocardial infarction: fact or fiction? A systemic review and meta-analysis</atitle><jtitle>Cancer management and research</jtitle><addtitle>Cancer Manag Res</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>11</volume><spage>1959</spage><epage>1968</epage><pages>1959-1968</pages><issn>1179-1322</issn><eissn>1179-1322</eissn><abstract>Accumulating evidences showed some positive relations between myocardial infarction (MI) and new onset cancer. We aim to investigate whether MI is associated with an increased risk of incident cancer.
A comprehensive literature list was identified from MEDLINE, Embase, and Web of Science databases from inception until October 2018. The main inclusion criteria included observational studies investigating the association between MI and new onset cancer. Stata 12.0 software was used for meta-analysis.
Of 862 potentially relevant studies, five cohort studies met all inclusion criteria. The pooled cancer incidence rate was 9.5% (95% CI=8.3-10.7%). Pooled analysis of OR showed that the increased overall cancer risk in MI patients in comparison with controls had no statistical significance (OR=1.08; 95% CI=0.97-1.19,
0.153). Subgroup analysis by gender demonstrated that the overall cancer risk was only significantly increased in female (OR=1.10; 95% CI=1.01-1.20,
0.025), but not in male patients (OR=1.04; 95% CI=0.99-1.10,
=0.124). In terms of cancer type, the increased cancer risk was only significant for lung cancer (male OR=1.12; 95% CI=1.05-1.19,
<0.01; and female OR=1.51; 95% CI=1.15-1.99,
<0.01), but not for prostate (OR=0.96; 95% CI=0.85-1.09,
0.546) or breast cancer (OR=0.94; 95% CI=0.86-1.04,
0.222). In addition, the increased cancer risk was only significant in the first 6 months (OR=1.93; 95% CI=1.42-2.63,
<0.01) but not in 6 months-1-year (OR=1.03; 95% CI=0.92-1.15,
0.627) or >1-year (OR=0.98; 95% CI=0.93-1.04,
=0.585) follow-up after MI.
From available evidence, the increased overall cancer risk after MI was only significant in female but not in male patients. Besides, the increased cancer risk could be driven by increased short-term cancer incidence after MI and certain cancer types such as lung cancer.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>30881121</pmid><doi>10.2147/CMAR.S193658</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1179-1322 |
| ispartof | Cancer management and research, 2019-03, Vol.11, p.1959-1968 |
| issn | 1179-1322 1179-1322 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_f49fadeb1c464952b70f39abd119f01c |
| source | Publicly Available Content Database; Taylor & Francis Open Access Journals; PubMed Central |
| subjects | Cancer Cardiac patients Health aspects Heart attack incident cancer Lung cancer meta-analysis myocardial infarction Oncology, Experimental Online databases Original Research Risk factors |
| title | Increased cancer risk after myocardial infarction: fact or fiction? A systemic review and meta-analysis |
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