Neurotechnological Approaches to the Diagnosis and Treatment of Alzheimer's Disease

Alzheimer's disease (AD) is the most common cause of dementia in the elderly, clinically defined by progressive cognitive decline and pathologically, by brain atrophy, neuroinflammation, and accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles. Neurotechnologi...

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Bibliographic Details
Published in:Frontiers in neuroscience 2022-03, Vol.16, p.854992-854992
Main Authors: Ning, Shen, Jorfi, Mehdi, Patel, Shaun R, Kim, Doo Yeon, Tanzi, Rudolph E
Format: Article
Language:English
Subjects:
Alzheimer’s disease
amyloid
diagnosis
Neuroscience
neurotechnologies
therapeutic
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Summary:Alzheimer's disease (AD) is the most common cause of dementia in the elderly, clinically defined by progressive cognitive decline and pathologically, by brain atrophy, neuroinflammation, and accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles. Neurotechnological approaches, including optogenetics and deep brain stimulation, have exploded as new tools for not only the study of the brain but also for application in the treatment of neurological diseases. Here, we review the current state of AD therapeutics and recent advancements in both invasive and non-invasive neurotechnologies that can be used to ameliorate AD pathology, including neurostimulation via optogenetics, photobiomodulation, electrical stimulation, ultrasound stimulation, and magnetic neurostimulation, as well as nanotechnologies employing nanovectors, magnetic nanoparticles, and quantum dots. We also discuss the current challenges in developing these neurotechnological tools and the prospects for implementing them in the treatment of AD and other neurodegenerative diseases.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2022.854992