SHEAR saliva collection device augments sample properties for improved analytical performance

Despite being a convenient clinical substrate for biomonitoring, saliva's widespread utilization has not yet been realized. The non-Newtonian, heterogenous, and highly viscous nature of saliva complicate the development of automated fluid handling processes that are vital for accurate diagnoses...

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Bibliographic Details
Published in:Bioengineering & translational medicine 2023-11, Vol.8 (6), p.e10490-n/a
Main Authors: Song, Shang Wei, Gupta, Rashi, Jothilingam, Niharika, Qian, Xinlei, Gu, Yue, Lee, V Vien, Sapanel, Yoann, Allen, David Michael, Wong, John Eu Li, MacAry, Paul, Ho, Dean, Blasiak, Agata
Format: Article
Language:English
Subjects:
antigen rapid test
Antigens
Biomonitoring
Collection
COVID-19
Disease transmission
Food
Glycoproteins
Homogenization
infectious diseases
Laboratory equipment
Pandemics
Pathogens
point‐of‐care
Product design
Reagents
Saliva
saliva collection device
saliva‐based diagnostic
sample homogenizer
Severe acute respiratory syndrome coronavirus 2
Shear
Substrates
User experience
Viscosity
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Summary:Despite being a convenient clinical substrate for biomonitoring, saliva's widespread utilization has not yet been realized. The non-Newtonian, heterogenous, and highly viscous nature of saliva complicate the development of automated fluid handling processes that are vital for accurate diagnoses. Furthermore, conventional saliva processing methods are resource and/or time intensive precluding certain testing capabilities, with these challenges aggravated during a pandemic. The conventional approaches may also alter analyte structure, reducing application opportunities in point-of-care diagnostics. To overcome these challenges, we introduce the SHEAR saliva collection device that mechanically processes saliva, in a rapid and resource-efficient way. We demonstrate the device's impact on reducing saliva's viscosity, improving sample's uniformity, and increasing diagnostic performance of a COVID-19 rapid antigen test. Additionally, a formal user experience study revealed generally positive comments. SHEAR saliva collection device may support realization of the saliva's potential, particularly in large-scale and/or resource-limited settings for global and community diagnostics.
ISSN:2380-6761
2380-6761
DOI:10.1002/btm2.10490