Composite odontoma: An enigmatic impeder to the permanent teeth – Report of two cases with emphasis on molecular pathogenesis

Odontome is the most common odontogenic tumour impeding the eruption of teeth. They are considered as hamartomatous malformations rather than true neoplasms. Usually, asymptomatic in nature and associated with unerupted permanent tooth. Compound and complex are the two types described by the World H...

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Bibliographic Details
Published in:Oral oncology reports 2024-06, Vol.10, p.100155, Article 100155
Main Authors: Vinoth, Vasanthi, Annasamy, Ramesh Kumar, Krishnan, Rajkumar, Krishnan, Velavan
Format: Article
Language:English
Subjects:
Enamel matrix
Eruption
Ghost cells
Odontoma
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Summary:Odontome is the most common odontogenic tumour impeding the eruption of teeth. They are considered as hamartomatous malformations rather than true neoplasms. Usually, asymptomatic in nature and associated with unerupted permanent tooth. Compound and complex are the two types described by the World Health Organization. Hyperactive odontoblasts, inflammation, infection, trauma and genetic aberrations have been implicated as the factors contributing to the formation of odontoma. Aberrant Wnt/β-catenin signaling pathway and sonic hedgehog pathway were considered to contribute to the development of odontoma. We report two teenagers with complaint of unerupted permanent teeth as a consequence of hamartomatous odontoma in the path of eruption of permanent teeth. •Only few cases of composite odontoma reported so far.•Enamel matrix like areas with fish scale appearance was notFiced in both the patients.•Ghost cells were seen in association with calcified tissue.
ISSN:2772-9060
2772-9060
DOI:10.1016/j.oor.2024.100155