Synthesis and evaluation of some new 1,2,4-triazolo(4,3-a)quinoxalin-4-5H-one derivatives as AMPA receptor antagonists

This study involves the synthesis and anticonvulsant evaluation of 1-ethyl-3-hydrazinylquinoxalin-2-1H-one (8), and many other newly synthesized compounds (9–14). The structure of the synthesized compounds was confirmed by elemental analysis and spectral data (IR, 1H NMR and Mass). Docking studies w...

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Bibliographic Details
Published in:Bulletin of the Faculty of Pharmacy 2012-12, Vol.50 (2), p.141-146
Main Authors: Bayoumi, Ashraf, Ghiaty, Adel, El-Morsy, Ahmed, Abul-Khair, Hamada, Hassan, Memy H., Elmeligie, Salwa
Format: Article
Language:English
Subjects:
Anticonvulsant
Quinoxalinone
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Summary:This study involves the synthesis and anticonvulsant evaluation of 1-ethyl-3-hydrazinylquinoxalin-2-1H-one (8), and many other newly synthesized compounds (9–14). The structure of the synthesized compounds was confirmed by elemental analysis and spectral data (IR, 1H NMR and Mass). Docking studies were performed to all the synthesized compounds in order to rationalize the anticonvulsant activity of the proposed compounds in a qualitative way. There is a strong correlation between the results of molecular modeling and the anticonvulsant activity of the synthesized compounds. The highest fitting value was noticed for compounds 9 and 10 “which showed the highest anticonvulsant activity”. [Display omitted]
ISSN:1110-0931
2090-9101
DOI:10.1016/j.bfopcu.2012.05.002