Molecular biology of rotavirus entry and replication

Rotavirus is a nonenveloped, double-stranded, RNA virus belonging to the Reoviridae family and is the major etiological agent of viral gastroenteritis in young children and young animals. Remarkable progress in the understanding of the rotavirus cycle has been made in the last 10 years. The knowledg...

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Bibliographic Details
Published in:TheScientificWorld 2009-01, Vol.9, p.1476-1497
Main Authors: Ruiz, Marie Christine, Leon, Theresa, Diaz, Yuleima, Michelangeli, Fabian
Format: Article
Language:English
Subjects:
Animals
Calcium - physiology
Development and progression
DNA replication
Endoplasmic Reticulum - virology
Genetic aspects
Humans
Molecular biology
Physiological aspects
Review
Rotavirus - physiology
Rotavirus infections
Rotavirus Infections - virology
Viral genetics
Viral Regulatory and Accessory Proteins - physiology
Viral Structural Proteins - physiology
Virion - physiology
Virus Internalization
Virus Replication - physiology
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Summary:Rotavirus is a nonenveloped, double-stranded, RNA virus belonging to the Reoviridae family and is the major etiological agent of viral gastroenteritis in young children and young animals. Remarkable progress in the understanding of the rotavirus cycle has been made in the last 10 years. The knowledge of viral replication thus far acquired is based on structural studies, the expression and coexpression of individual viral proteins, silencing of individual genes by siRNAs, and the effects that these manipulations have on the physiology of the infected cell. The functions of the individual rotavirus proteins have been largely dissected; however, the interactions between them and with cell proteins, and the molecular mechanisms of virus replication, are just beginning to be understood. These advancements represent the basis for the development of effective vaccination and rational therapeutic strategies to combat rotavirus infection and diarrhea syndromes. In this paper, we review and try to integrate the new knowledge about rotavirus entry, replication, and assembly, and pose some of the questions that remain to be solved.
ISSN:1537-744X
2356-6140
1537-744X
DOI:10.1100/tsw.2009.158