Nanoarchitectured air-stable supported lipid bilayer incorporating sucrose–bicelle complex system

Cell-membrane-mimicking supported lipid bilayers (SLBs) provide an ultrathin, self-assembled layer that forms on solid supports and can exhibit antifouling, signaling, and transport properties among various possible functions. While recent material innovations have increased the number of practicall...

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Bibliographic Details
Published in:Nano convergence 2022-01, Vol.9 (1), p.3-10, Article 3
Main Authors: Tae, Hyunhyuk, Park, Soohyun, Ma, Gamaliel Junren, Cho, Nam-Joon
Format: Article
Language:English
Subjects:
Adsorption
Air stability
Aqueous environments
Bicelle
Chemistry and Materials Science
Complex systems
Crystal defects
Dehydration
Fluorescence
Lipids
Materials Science
Membranes
Nanoscale Science and Technology
Nanotechnology
Nanotechnology and Microengineering
Quartz crystals
Self-assembly
Sucrose
Supported lipid bilayer
Transport properties
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Summary:Cell-membrane-mimicking supported lipid bilayers (SLBs) provide an ultrathin, self-assembled layer that forms on solid supports and can exhibit antifouling, signaling, and transport properties among various possible functions. While recent material innovations have increased the number of practically useful SLB fabrication methods, typical SLB platforms only work in aqueous environments and are prone to fluidity loss and lipid-bilayer collapse upon air exposure, which limits industrial applicability. To address this issue, herein, we developed sucrose–bicelle complex system to fabricate air-stable SLBs that were laterally mobile upon rehydration. SLBs were fabricated from bicelles in the presence of up to 40 wt% sucrose, which was verified by quartz crystal microbalance-dissipation (QCM-D) and fluorescence recovery after photobleaching (FRAP) experiments. The sucrose fraction in the system was an important factor; while 40 wt% sucrose induced lipid aggregation and defects on SLBs after the dehydration–rehydration process, 20 wt% sucrose yielded SLBs that exhibited fully recovered lateral mobility after these processes. Taken together, these findings demonstrate that sucrose–bicelle complex system can facilitate one-step fabrication of air-stable SLBs that can be useful for a wide range of biointerfacial science applications.
ISSN:2196-5404
2196-5404
DOI:10.1186/s40580-021-00292-5