Determination of phytochemical contents by LC/QTOF/MS and evaluation of in-vitro biological activities of 2 Peltigera lichens from Bursa

Lichens are symbiotic associations of algae and fungi. They are edible as food and have been used in traditional medicine for years. It is aimed to screen Peltigera praetextata (Flörke ex Sommerf.) Zopfand and Peltigera elisabethae Gyeln. phytochemically by LC/QTOF/MS and according to the constituen...

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Published in:Anais da Academia Brasileira de Ciências 2024-01, Vol.96 (2), p.e20230657
Main Authors: Tüzün, Burcu S, Karadağ, Başak T, Oran, Seyhan, Öztürk, Şule, Yilmaz, Fethiye F, Fafal, Tuğçe, Kivçak, Bijen
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antioxidant
Antioxidants - analysis
Antioxidants - pharmacology
Chromatography, Liquid - methods
LC/QTOF/MS
Lichen phenolics
Lichens - chemistry
Mass Spectrometry - methods
Monophenol Monooxygenase - antagonists & inhibitors
MULTIDISCIPLINARY SCIENCES
Peltigera elisabethae Gyeln
Peltigera praetextata (Flörke ex Sommerf.)
Phytochemicals - analysis
Phytochemicals - chemistry
Phytochemicals - pharmacology
Tyrosinase inhibitor
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Summary:Lichens are symbiotic associations of algae and fungi. They are edible as food and have been used in traditional medicine for years. It is aimed to screen Peltigera praetextata (Flörke ex Sommerf.) Zopfand and Peltigera elisabethae Gyeln. phytochemically by LC/QTOF/MS and according to the constituents to evaluate the antioxidant, tyrosinase inhibitory, and antibacterial activities. In total 54 of metabolites detected by LC/QTOF/MS were common in both species. According to LC/QTOF/MS scanning results, alkaloids, iridoid glycosides, phenolics, cyanogenetic glycosides, and terpenic structures were detected. DPPH, ABTS, superoxide radical scavenging activities, and metal chelating capacity IC50 values were 84.55, 9.349; 51.27, 9.127; 95.01, 58.65 and 20.57, 70.08 µg/mL., respectively. The CUPRAC reducing power was determined as 4.69 and 9.57 TEACCUPRAC, respectively. Tyrosinase inhibitor activity were found to be 86.95 and 196.7 µg/mL. Both lichens did not show antimicrobial effects. As a result of the antioxidant and tyrosinase inhibitor activities it was seen that their activities were significant and further in vivo studies could be carried out on this lichens.
ISSN:1678-2690
1678-2690
DOI:10.1590/0001-3765202420230657