Diamond, graphite, and graphene oxide nanoparticles decrease migration and invasiveness in glioblastoma cell lines by impairing extracellular adhesion

The highly invasive nature of glioblastoma is one of the most significant problems regarding the treatment of this tumor. Diamond nanoparticles (ND), graphite nanoparticles (NG), and graphene oxide nanoplatelets (nGO) have been explored for their biomedical applications, especially for drug delivery...

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Bibliographic Details
Published in:International journal of nanomedicine 2017-01, Vol.12, p.7241-7254
Main Authors: Wierzbicki, Mateusz, Jaworski, Sławomir, Kutwin, Marta, Grodzik, Marta, Strojny, Barbara, Kurantowicz, Natalia, Zdunek, Krzysztof, Chodun, Rafał, Chwalibog, André, Sawosz, Ewa
Format: Article
Language:English
Subjects:
Autophagy
Brain cancer
Cancer
Carbon
Cell adhesion & migration
Cytoskeleton
Diamond
Epidermal growth factor
Extracellular matrix
glioblastoma
Graphene
graphene oxide
graphite
invasiveness
Kinases
Lasers
Ligands
Medical prognosis
Metastasis
migration
Morphology
Motility
Mutation
Nanomaterials
Nanoparticles
Original Research
Phosphorylation
Scanning electron microscopy
Spectrum analysis
Tumors
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Summary:The highly invasive nature of glioblastoma is one of the most significant problems regarding the treatment of this tumor. Diamond nanoparticles (ND), graphite nanoparticles (NG), and graphene oxide nanoplatelets (nGO) have been explored for their biomedical applications, especially for drug delivery. The objective of this research was to assess changes in the adhesion, migration, and invasiveness of two glioblastoma cell lines, U87 and U118, after ND, NG, and nGO treatment. All treatments affected the cell surface structure, adhesion-dependent EGFR/AKT/mTOR, and β-catenin signaling pathways, decreasing the migration and invasiveness of both glioblastoma cell lines. The examined nanoparticles did not show strong toxicity but effectively deregulated cell migration. ND was effectively taken up by cells, whereas nGO and NG strongly interacted with the cell surface. These results indicate that nanoparticles could be used in biomedical applications as a low toxicity active compound for glioblastoma treatment.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S146193