Non-O1, Non-O139 Vibrio cholerae Bacteremia in an Autoimmune Pancreatitis Patient

Over 200 different serogroups of Vibrio cholerae based on O-polysaccharide specificity have been described worldwide, including the two most important serogroups, O1 and O139. Non-O1/non-O139 V. cholerae serogroups generally do not produce the cholera-causing toxin but do sporadically cause gastroen...

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Bibliographic Details
Published in:Case reports in infectious diseases 2024-05, Vol.2024, p.7219952-4
Main Authors: Gu, Cheng-Jing, Ding, Ming-Dong, Zhou, Da-Ming, Li, Jie, Yu, Wen-Qing, Yang, Yong-Lin
Format: Article
Language:English
Subjects:
Abdomen
Antigens
Bacteremia
Bile ducts
Blood
China
Cholera
Cholera toxin
Contamination
Diabetes
Diarrhea
Fever
Gastroenteritis
Health aspects
Hepatitis
Immunoglobulins
Infection
Infections
Kinases
Leukocytes
Liver cirrhosis
Medical examination
Mortality
Neutrophils
Pancreatitis
Patients
Potassium
Remission (Medicine)
Seafood
Steroids
Tetracycline
Tetracyclines
Toxins
Virulence
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Summary:Over 200 different serogroups of Vibrio cholerae based on O-polysaccharide specificity have been described worldwide, including the two most important serogroups, O1 and O139. Non-O1/non-O139 V. cholerae serogroups generally do not produce the cholera-causing toxin but do sporadically cause gastroenteritis and extra-intestinal infections. Recently, however, bloodstream infections caused by non-O1/non-O139 V. cholerae are being increasingly reported, and these infections are associated with high mortality in immunocompromised hosts. We describe a case of non-O1/non-O139 V. cholerae bacteremia in a patient with autoimmune pancreatitis and stenosis of the intra- and extrahepatic bile ducts. The clinical manifestations of bacteremia were fever and mild digestive symptoms. The blood cultures showed V. cholerae, which was identified as a non-O1, non-O139 serogroup by slide agglutination tests and PCR. The bloodstream infection of the patient was likely caused by the consumption of contaminated seafood at a banquet. The patient recovered after the administration of a third-generation cephalosporin. Non-O1/non-O139 V. cholerae infection presents with or without gastrointestinal manifestations; close attention should be paid to the possibility of disseminated non-O1/non-O139 V. cholerae infection in high-risk patients.
ISSN:2090-6625
2090-6633
DOI:10.1155/2024/7219952