Anti-Inflammatory Drugs as Anticancer Agents

Inflammation is strictly associated with cancer and plays a key role in tumor development and progression. Several epidemiological studies have demonstrated that inflammation can predispose to tumors, therefore targeting inflammation and the molecules involved in the inflammatory process could repre...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-04, Vol.21 (7), p.2605
Main Authors: Zappavigna, Silvia, Cossu, Alessia Maria, Grimaldi, Anna, Bocchetti, Marco, Ferraro, Giuseppe Andrea, Nicoletti, Giovanni Francesco, Filosa, Rosanna, Caraglia, Michele
Format: Article
Language:English
Subjects:
5-LOX inhibitors
Angiogenesis
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Antitumor activity
Apoptosis
Biomarkers
Cancer
Cancer therapies
Cell adhesion & migration
Cell growth
Chemokines
Chemoprevention
Clinical trials
COX-2 inhibitors
Cyclooxygenase 2 Inhibitors - pharmacology
Cyclooxygenase 2 Inhibitors - therapeutic use
Cytokines
Deoxyribonucleic acid
DNA
DNA damage
DNA repair
Drug Repositioning
embelin
Endothelium
Epidemiology
Growth factors
Humans
Inflammation
Inflammation - complications
Inflammation - drug therapy
Inflammation Mediators - metabolism
inflammation-associated cancer
Inflammatory bowel disease
Lymphocytes
Metastasis
Mutation
Neoplasms - drug therapy
Neoplasms - etiology
Neoplasms - prevention & control
Neutrophils
Nonsteroidal anti-inflammatory drugs
NSAIDs
Review
Signal Transduction
Tumor necrosis factor-TNF
Tumorigenesis
Tumors
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Description
Summary:Inflammation is strictly associated with cancer and plays a key role in tumor development and progression. Several epidemiological studies have demonstrated that inflammation can predispose to tumors, therefore targeting inflammation and the molecules involved in the inflammatory process could represent a good strategy for cancer prevention and therapy. In the past, several clinical studies have demonstrated that many anti-inflammatory agents, including non-steroidal anti-inflammatory drugs (NSAIDs), are able to interfere with the tumor microenvironment by reducing cell migration and increasing apoptosis and chemo-sensitivity. This review focuses on the link between inflammation and cancer by describing the anti-inflammatory agents used in cancer therapy, and their mechanisms of action, emphasizing the use of novel anti-inflammatory agents with significant anticancer activity.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21072605