The antimicrobial efficacy of nanographene oxide and double antibiotic paste per se and in combination: part II

Finding strategies to overcome the rising trends of antimicrobial resistance against currently available antimicrobial agents has become increasingly relevant. Graphene oxide has recently emerged as a promising material due to its outstanding physicochemical and biological properties. This study aim...

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Published in:BMC oral health 2023-05, Vol.23 (1), p.253-253, Article 253
Main Authors: Eskandari, Fateme, Ghahramani, Yasamin, Abbaszadegan, Abbas, Gholami, Ahmad
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-infective agents
Anti-Infective Agents - pharmacology
Anti-Infective Agents - therapeutic use
Antibacterial activity
Antibacterial agents
Antibiotics
Antimicrobial
Antimicrobial activity
Antimicrobial agents
Antimicrobial resistance
Bacteria
Biocompatibility
Biofilms
Biomedical
Carbon
Ciprofloxacin
Composition
Dentifrices
Dentistry
Dosage and administration
Double antibiotic paste
Drug resistance
Drug resistance in microorganisms
Efficiency
Endodontics
Escherichia coli
Gram-negative bacteria
Gram-positive bacteria
Graphene
Graphite
Health aspects
Humans
Metronidazole
Microbial Sensitivity Tests
Microorganisms
Microscopy
Nanomaterials
Nanotechnology
Oxides - chemistry
Oxides - pharmacology
Oxides - therapeutic use
Pathogens
Prevention
Quantum dots
Staphylococcus aureus
Statistical analysis
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Summary:Finding strategies to overcome the rising trends of antimicrobial resistance against currently available antimicrobial agents has become increasingly relevant. Graphene oxide has recently emerged as a promising material due to its outstanding physicochemical and biological properties. This study aimed to validate previous data on the antibacterial activity of nanographene oxide (nGO), double antibiotic paste (DAP), and their combination (nGO-DAP). The antibacterial evaluation was performed against a wide range of microbial pathogens. Synthesis of nGO was achieved using a modified Hummers' method, and loading it with ciprofloxacin and metronidazole resulted in nGO-DAP. The microdilution method was utilized to assess the antimicrobial efficacy of nGO, DAP, and nGO-DAP against two gram-positive bacteria (S. aureus and E. faecalis), two gram-negative bacteria (E. coli, and S. typhi), and an opportunistic pathogenic yeast (C. albicans). Statistical analysis was conducted using one-sample t-test and one-way ANOVA (α = 0.05). All three antimicrobial agents significantly increased the killing percent of microbial pathogens compared to the control group (P 
ISSN:1472-6831
1472-6831
DOI:10.1186/s12903-023-02957-5