Changes in the quality of medicines during storage under LED lighting and consideration of countermeasures

In recent years, the popularity of LED lighting has rapidly increased, owing to its many advantages, including economic benefits. We examined the change in the quality of drugs during storage under LED and fluorescent lighting and found that some medicines exhibited a different degree of color chang...

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Bibliographic Details
Published in:Journal of pharmaceutical health care and sciences 2018-06, Vol.4 (1), p.12-12, Article 12
Main Authors: Yamashita, Shuuji, Iguchi, Kazuhiro, Noguchi, Yoshihiro, Sakai, Chihiro, Yokoyama, Satoshi, Ino, Yoko, Hayashi, Hideki, Teramachi, Hitomi, Sako, Magoichi, Sugiyama, Tadashi
Format: Article
Language:English
Subjects:
Analysis
Color
Color change
Drug stores
Drugs
Fluorescent lighting
Humidity
Laboratories
LED lighting
Light emitting diodes
Medicine
Medicines
Pharmaceuticals
Pharmacy
Photostability
Plastic containers
Quality standards
Short Report
Spectrum analysis
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Summary:In recent years, the popularity of LED lighting has rapidly increased, owing to its many advantages, including economic benefits. We examined the change in the quality of drugs during storage under LED and fluorescent lighting and found that some medicines exhibited a different degree of color change depending on the light source. The purpose of this study was to investigate the effects of different plastic storage bags on the color change over time when various medicines were stored under LED and fluorescent lighting conditions. Photostability tests were conducted on several types of target drugs. Subsequently, subjective evaluation by ten evaluators and objective evaluation by image analysis software were carried out regarding color change. A similar change in color tone was observed after all types of illumination. Subjective evaluation by 10 evaluators revealed that "change in color tone" occurred in the order of bulb-color LED lighting < daylight-color LED lighting < fluorescent lighting, regardless of the type of plastic bags. A similar tendency was observed also in objective evaluation. In this study, it was considered that a brown light-shielding plastic bag was more effective than a normal plastic bag for the prevention of the color change of medicines stored under LED lighting. The above results suggested that the most appropriate combination of plastic bag and light source for medicine storage was a brown light-shielding plastic bag and bulb-color LED lighting.
ISSN:2055-0294
2055-0294
DOI:10.1186/s40780-018-0108-0