Quantification of cerebrospinal fluid ferritin as a biomarker for CNS malignant infiltration Quantificação de ferritina no líquido cefalorraquidiano como biomarcador para o diagnóstico de infiltração maligna no SNC

Several markers have been studied for their ability to make the CNS infiltration diagnosis earlier and more precise; previous studies showed that CSF ferritin concentrations were higher in patients with malignant invasion of CNS. The objective was to determine the importance of CSF ferritin as a bio...

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Published in:Arquivos de neuro-psiquiatria 2008-01, Vol.66 (3b), p.720-724
Main Authors: Sérgio Monteiro de Almeida, Dione Sosnitzki da Cunha, Edna Yamada, Elvira Missako Doi, Margaret Ono
Format: Article
Language:English
Subjects:
bacterial meningitis
central nervous system
cerebrospinal fluid
CNS neoplasm
CNS tumors
células malignas
ferritin
líquido cefalorraquidiano
malignant cells
meningites bacterianas
neoplasias do SNC
sistema nervoso central
tumores do SNC
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Summary:Several markers have been studied for their ability to make the CNS infiltration diagnosis earlier and more precise; previous studies showed that CSF ferritin concentrations were higher in patients with malignant invasion of CNS. The objective was to determine the importance of CSF ferritin as a biomarker for the diagnosis of CNS neoplasic infiltration. This study is based on 93 CSF samples, divided into five groups: malignant cells present (n13); malignant cells not present (n26); inflammatory neurological diseases (n16); neurocysticercosis (n20); acute bacterial meningitis (n18). CSF ferritin values were determined by micro particle enzyme immunoassay. CSF ferritin level (mean±SD) in the group with neoplasic cells in the CSF was 42.8±49.7 ng /mL, higher than in the other groups (p
ISSN:0004-282X
1678-4227
DOI:10.1590/S0004-282X2008000500022