Neuroinflammation: A Possible Link Between Chronic Vascular Disorders and Neurodegenerative Diseases

Various age-related diseases involve systemic inflammation, i.e. a stereotyped series of acute immune system responses, and aging itself is commonly associated with low-grade inflammation or inflamm'aging. Neuroinflammation is defined as inflammation-like processes inside the central nervous sy...

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Bibliographic Details
Published in:Frontiers in aging neuroscience 2022-05, Vol.14, p.827263-827263
Main Authors: Moyse, Emmanuel, Krantic, Slavica, Djellouli, Nesrine, Roger, Sébastien, Angoulvant, Denis, Debacq, Camille, Leroy, Victoire, Fougere, Bertrand, Aidoud, Amal
Format: Article
Language:English
Subjects:
Aging
Alzheimer's disease
Arteriosclerosis
astrocytes
Brain
Cardiovascular diseases
Central nervous system
Chemokines
Chronic illnesses
Cytokines
Immune system
Inflammation
Ischemia
ischemia-reperfusion
Life Sciences
Macrophages
Microglia
Morphology
Nervous system
Neurodegeneration
Neurodegenerative diseases
neuroinflammation
Neuroscience
Pathogens
Pathology
Risk factors
Transcriptomics
Vein & artery diseases
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Summary:Various age-related diseases involve systemic inflammation, i.e. a stereotyped series of acute immune system responses, and aging itself is commonly associated with low-grade inflammation or inflamm'aging. Neuroinflammation is defined as inflammation-like processes inside the central nervous system, which this review discusses as a possible link between cardiovascular disease-related chronic inflammation and neurodegenerative diseases. To this aim, neuroinflammation mechanisms are first summarized, encompassing the cellular effectors and the molecular mediators. A comparative survey of the best-known physiological contexts of neuroinflammation (neurodegenerative diseases and transient ischemia) reveals some common features such as microglia activation. The recently published transcriptomic characterizations of microglia have pointed a marker core signature among neurodegenerative diseases, but also unraveled the discrepancies with neuroinflammations related with acute diseases of vascular origin. We next review the links between systemic inflammation and neuroinflammation, beginning with molecular features of respective pro-inflammatory cells, i.e. macrophages and microglia. Finally, we point out a gap of knowledge concerning the atherosclerosis-related neuroinflammation, which is for the most surprising given that atherosclerosis is established as a major risk factor for neurodegenerative diseases.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2022.827263