Association of catechol-O-methyltransferase gene polymorphism with benign prostatic hyperplasia in Babylon Province

Background : Benign prostatic hyperplasia (BPH) is a common nonmalignant disorder in elderly men. Objectives : The objective of the present study was planned to evaluate the frequency and association of catechol-O-methyltransferase (COMT) gene G↔A (Val 158 Met)single-nucleotide polymorphism (SNP) wi...

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Bibliographic Details
Published in:Medical Journal of Babylon 2020, Vol.17 (1), p.54-57
Main Authors: Husayn, Nibras Yahya, al-Salman, Abd al-Razzaq, Awdah, Mufid J.
Format: Article
Language:English
Subjects:
benign prostatic hyperplasia
catechol-o-methyltransferase
Development and progression
Genetic aspects
Genetic research
Health aspects
polymorphism
Prostatic hyperplasia
Risk factors
Single nucleotide polymorphisms
Transferases
الأورام الحميدة
البروستات
الفينولات
فرط التنسج
ميتيل-ترانسفيراز
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Summary:Background : Benign prostatic hyperplasia (BPH) is a common nonmalignant disorder in elderly men. Objectives : The objective of the present study was planned to evaluate the frequency and association of catechol-O-methyltransferase (COMT) gene G↔A (Val 158 Met)single-nucleotide polymorphism (SNP) with BPH in Babylon Province. Materials and Methods : To accomplish this purpose, 146 patients with BPH and 102 apparently healthy controls were subjected to the study. DNA was extracted from whole blood for all samples. Genotyping of COMT gene G↔A (Val 158 Met) SNP was carried out by allele specific oligonucleotides polymerase chain reaction. Results: Results indicated that the homozygous genotype (Met158Met) (AA) of COMT gene G↔A (Val 158 Met) SNP was found to be significantly increase the risk of BPH by three folds with respect to those of the wild genotype (Val158Val) (GG) of COMT gene G↔A (Val 158 Met) SNP. The heterozygous genotype (Val158Met) (GA) of COMT gene G↔A (Val 158 Met) SNP was found to be none significantly increase the risk of BPH with respect to those of the wild genotype (Val158Val) (GG) of COMT gene G↔A (Val 158 Met) SNP. The minor allele frequencies (A) of COMT gene G↔A (Val 158 Met) SNP were significantly higher in BPH patients when compared with that of the control group. Conclusions: The COMT gene G↔A (Val 158 Met) SNP is involved in the pathogenesis of BPH
ISSN:1812-156X
2312-6760
DOI:10.4103/MJBL.MJBL_83_19