Recovery of polyclonal immunoglobulins one year after autologous stem cell transplantation as a long-term predictor marker of progression and survival in multiple myeloma

• Published in: Haematologica (Roma) 2017-05, Vol.102 (5), p.922-931
• Main Authors: González-Calle, Verónica, Cerdá, Seila, Labrador, Jorge, Sobejano, Eduardo, González-Mena, Beatriz, Aguilera, Carmen, Ocio, Enrique María, Vidriales, María Belén, Puig, Noemí, Gutiérrez, Norma Carmen, García-Sanz, Ramón, Alonso, José María, López, Rosa, Aguilar, Carlos, de Coca, Alfonso García, Hernández, Roberto, Hernández, José Mariano, Escalante, Fernando, Mateos, María-Victoria
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biomarkers, Tumor - metabolism; Disease Progression; Female; Hematopoietic Stem Cell Transplantation - methods; Humans; Immunoglobulins - metabolism; Kaplan-Meier Estimate; Male; Middle Aged; Multiple Myeloma - metabolism; Multiple Myeloma - pathology; Multiple Myeloma - therapy; Outcome Assessment (Health Care) - methods; Outcome Assessment (Health Care) - statistics & numerical data; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Retrospective Studies; Time Factors; Transplantation, Autologous
• ISSN: 0390-6078; 1592-8721
• DOI: 10.3324/haematol.2016.158345

Immunoparesis or suppression of polyclonal immunoglobulins is a very common condition in newly diagnosed myeloma patients. However, the recovery of polyclonal immunoglobulins in the setting of immune reconstitution after autologous stem cell transplantation and its effect on outcome has not yet been explored. We conducted this study in a cohort of 295 patients who had undergone autologous transplantation. In order to explore the potential role of immunoglubulin recovery as a dynamic predictor of progression or survival after transplantation, conditional probabilities of progression-free survival and overall survival were estimated according to immunoglobulin recovery at different time points using a landmark approach. One year after transplant, when B-cell reconstitution is expected to be completed, among 169 patients alive and progression free, 88 patients (52%) showed immunoglobulin recovery and 81 (48%) did not. Interestingly, the group with immunoglobulin recovery had a significantly longer median progression-free survival than the group with persistent immunoparesis (median 60.4 27.9 months, respectively; Hazard Ratio: 0.45, 95%Confidence Interval: 0.31-0.66;