Gingers and Their Purified Components as Cancer Chemopreventative Agents

Chemoprevention by ingested substituents is the process through which nutraceuticals and/or their bioactive components antagonize carcinogenesis. Carcinogenesis is the course of action whereby a normal cell is transformed into a neoplastic cell. This latter action involves several steps, starting wi...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-08, Vol.24 (16), p.2859
Main Authors: Lechner, John F, Stoner, Gary D
Format: Article
Language:English
Subjects:
Animals
Anticarcinogenic Agents - chemistry
Anticarcinogenic Agents - pharmacology
Apoptosis
Biopsy
Cancer
cancer chemoprevention
Carcinogenesis
Carcinogens
Cell culture
Cell cycle
Chemoprevention
Colorectal cancer
Cytokines
Functional foods & nutraceuticals
Gene expression
gingerols
Humans
Inflammation
Kinases
Mutation
Normalizing
Ovaries
Oxidative stress
Pancreatic cancer
paradols
Phosphorylation
Plant Extracts - chemistry
Plant Extracts - pharmacology
Prostate
Proteins
Review
shogaols
Signal transduction
Structure-Activity Relationship
Tumors
zerumbone
zingerone
Zingiber officinale - chemistry
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Summary:Chemoprevention by ingested substituents is the process through which nutraceuticals and/or their bioactive components antagonize carcinogenesis. Carcinogenesis is the course of action whereby a normal cell is transformed into a neoplastic cell. This latter action involves several steps, starting with initiation and followed by promotion and progression. Driving these stages is continued oxidative stress and inflammation, which in turn, causes a myriad of aberrant gene expressions and mutations within the transforming cell population and abnormal gene expressions by the cells within the surrounding lesion. Chemoprevention of cancer with bioreactive foods or their extracted/purified components occurs primarily via normalizing these inappropriate gene activities. Various foods/agents have been shown to affect different gene expressions. In this review, we discuss how the chemoprevention activities of gingers antagonize cancer development.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24162859