Hydrogen peroxide preoxidation as a strategy for enhanced antimicrobial photodynamic action against methicillin-resistant Staphylococcus aureus

Antimicrobial photodynamic treatment (aPDT) is a photooxidative process based on the excitation of a photosensitizer (PS) in the presence of molecular oxygen, under specific wavelengths of light. It is a promising method for advanced treatment of water and wastewater, particularly targeting disinfec...

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Published in:Journal of water and health 2023-12, Vol.21 (12), p.1922-1932
Main Authors: Sammarro Silva, Kamila Jessie, Lima, Alessandra Ramos, Dias, Lucas Danilo, de Souza, Mariana, Nunes Lima, Thalita Hellen, Bagnato, Vanderlei Salvador
Format: Article
Language:English
Subjects:
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
curcumin
disinfection
Hydrogen Peroxide - pharmacology
Methicillin-Resistant Staphylococcus aureus
peroxidation
photodynamic inactivation
resistant bacteria
synergistic factor
Wastewater
Water
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Summary:Antimicrobial photodynamic treatment (aPDT) is a photooxidative process based on the excitation of a photosensitizer (PS) in the presence of molecular oxygen, under specific wavelengths of light. It is a promising method for advanced treatment of water and wastewater, particularly targeting disinfection challenges, such as antibiotic-resistant bacteria (ARB). Research in improved aPDT has been exploring new PS materials, and additives in general. Hydrogen peroxide (H O ) a widely applied disinfectant, mostly in the food industry and clinical settings, present environmentally negligible residuals at the usually applied concentrations, making it friendly for the water and wastewater sectors. Here, we explored the effects of preoxidation with H O followed by blue light-mediated (450 nm) aPDT using curcumin (a natural-based PS) against methicillin-resistant Staphylococcus aureus (MRSA). Results of the sequential treatment pointed to a slight hampering in aPDT efficiency at very low H O concentrations, followed by an increasing cooperative effect up to a deleterious point (≥7 log inactivation in CFU mL ), suggesting a synergistic interaction of preoxidation and aPDT. The increased performance in H O -pretreated aPDT encourages studies of optimal operational conditions for the assisted technology and describes potentials for using the described strategy to tackle the issue of ARB spread.
ISSN:1477-8920
1996-7829
DOI:10.2166/wh.2023.245