Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients

Background: Hypovitaminosis D is associated with oncogenesis, and the initial level of Vitamin D may play a role in determining long-term prognosis, relapse-free survival (RFS) and overall survival (OS). The purpose of our study was to follow up pediatric cancer patients for a long time in terms of...

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Bibliographic Details
Published in:Nutrients 2023-10, Vol.15 (21), p.4571
Main Authors: Kárász, Nóra, Juhász, Orsolya, Imrei, Marcell, Garami, Miklós
Format: Article
Language:English
Subjects:
Alfacalcidol
Calcifediol
Cancer
Cancer patients
Disease
Diseases
follow-up
Hematology
Hypotheses
Laboratories
Medical imaging
Medical prognosis
Neuroblastoma
Oncology, Experimental
overall survival
Patients
pediatric oncology
Pediatrics
Prognosis
Relapse
relapse-free survival
Remission (Medicine)
Statistical analysis
Thyroid gland
Tumors
Vitamin D
Vitamin deficiency
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Summary:Background: Hypovitaminosis D is associated with oncogenesis, and the initial level of Vitamin D may play a role in determining long-term prognosis, relapse-free survival (RFS) and overall survival (OS). The purpose of our study was to follow up pediatric cancer patients for a long time in terms of their baseline Vitamin D level and disease outcomes. Methods: We collected data on the initial 25(OH)D concentration in 117 children and examined their RFS and OS using Kaplan–Meier curves. Results: The initial 25(OH)D mean value in the relapsed group was 20.35 ng/mL (SE: 2.05) and in children without relapse it was 26.14 ng/mL (SE: 1.13). Both the relapse-free and overall Kaplan–Meier curves showed a tendency for children with lower serum Vitamin D concentrations to experience cancer recurrence or fatal outcomes sooner than patients with normal serum levels. Conclusions: Our results indicated a possible correlation between higher pretreatment serum Vitamin D concentrations and improved overall and relapse-free survival.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15214571