The role of B cells in heart failure and implications for future immunomodulatory treatment strategies

Despite numerous demonstrations that the immune system is activated in heart failure, negatively affecting patients' outcomes, no definitive treatment strategy exists directed to modulate the immune system. In this review, we present the evidence that B cells contribute to the development of hy...

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Bibliographic Details
Published in:ESC Heart Failure 2020-08, Vol.7 (4), p.1387-1399
Main Authors: García‐Rivas, Gerardo, Castillo, Elena Cristina, Gonzalez‐Gil, Adrian M., Maravillas‐Montero, José Luis, Brunck, Marion, Torres‐Quintanilla, Alejandro, Elizondo‐Montemayor, Leticia, Torre‐Amione, Guillermo
Format: Article
Language:English
Subjects:
Adrenergic receptors
Antibodies
Antigens
Apoptosis
B cells
Cardiac arrhythmia
Cardiomyocytes
Cardiomyopathy
Heart attacks
Heart failure
Immune system
Inflammation
Kinases
Proteins
Review
Signal transduction
Therapeutics
Tumor necrosis factor-TNF
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Summary:Despite numerous demonstrations that the immune system is activated in heart failure, negatively affecting patients' outcomes, no definitive treatment strategy exists directed to modulate the immune system. In this review, we present the evidence that B cells contribute to the development of hypertrophy, inflammation, and maladaptive tissue remodelling. B cells produce antibodies that interfere with cardiomyocyte function, which culminates as the result of recruitment and activation of a variety of innate and structural cell populations, including neutrophils, macrophages, fibroblasts, and T cells. As B cells appear as active players in heart failure, we propose here novel immunomodulatory therapeutic strategies that target B cells and their products.
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.12744