Cardiovascular Risk Predictors High Sensitivity C-Reactive Protein and Plasminogen Activator Inhibitor-1 in Women with Lean Phenotype of Polycystic Ovarian Syndrome: A Prospective Case-Control Study

• Published in: Journal of laboratory physicians 2023-03, Vol.15 (1), p.031-037
• Main Authors: Shah, Ashok K., Yadav, Birendra K., Shah, Amrendra K., Suri, Arpita, Deo, Saurabh K.
• Format: Article
• Language: English
• Subjects: cardiovascular disease; hs-CRP; lean phenotype of PCOS; Original; Original Article; PAI-1
• ISSN: 0974-2727; 0974-7826
• DOI: 10.1055/s-0042-1750066

Abstract Objective  Accumulating evidence suggests increased cardiovascular risk in women with polycystic ovarian syndrome (PCOS) due to a cluster of factors, such as obesity, lipid abnormalities, impaired glucose tolerance (IGT), and hypertension. Markers such as high-sensitivity C-reactive protein (hs-CRP) and plasminogen activator inhibitor-1 (PAI-1) can provide an adjunctive method for the assessment of cardiovascular risk and can indicate future coronary heart diseases in women with lean PCOS. Materials and Methods  In this prospective case-control study, women clinically diagnosed with PCOS ( n  = 25) with normal body mass index (BMI) and age and BMI-matched healthy controls ( n  = 75) were enrolled. The quantitative data were expressed as mean ± standard deviation (SD). Unpaired Student's t -test was used to compare the values (PCOS vs. controls) and Pearson's correlation coefficient was used to elucidate the relationship between the variables. Results  The mean level of fasting blood sugar, serum total cholesterol, low-density lipoprotein (LDL), thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), hs-CRP, and PAI-1 were significantly increased in PCOS patients ( p