Dietary restriction promote sperm remodeling in aged roosters based on transcriptome analysis

The breeder rooster has played a pivotal role in poultry production by providing high-quality semen. Typically, fertility peaks between 30 and 40 weeks of age and then declines rapidly from 45 to 55 weeks of age. Research into improving fertility in aging roosters is essential to extend their produc...

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Bibliographic Details
Published in:BMC genomics 2024-07, Vol.25 (1), p.680-11, Article 680
Main Authors: Liang, Wenjie, He, Yuehua, Zhu, Tingqi, Zhang, Binbin, Liu, Shuangxing, Guo, Haishan, Liu, Pingquan, Liu, Huayuan, Li, Donghua, Kang, Xiangtao, Li, Wenting, Sun, Guirong
Format: Article
Language:English
Subjects:
Aging
Aging - genetics
Analysis
Animals
Caloric Restriction
Chickens - genetics
Cytokines
Dietary restrictions
Enrichment
Fasting
Fertility
Fibroblast growth factor receptors
Gene expression
Gene Expression Profiling
Gene sequencing
Gene set enrichment analysis
Genes
Genetic aspects
Health aspects
Identification methods
Ligands
Male
MAP kinase
Molting
Motility
Poultry
Poultry production
Reproductive performance
Reproductive system
Ribonucleic acid
RNA
Roosters
Semen
Semen Analysis
Sequence analysis
Signal transduction
Sperm
Sperm Motility - genetics
Spermatogenesis
Spermatozoa
Spermatozoa - metabolism
Testis - metabolism
Transcriptome
Transcriptomes
Transforming growth factor-b
Transforming growth factors
Wnt protein
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Summary:The breeder rooster has played a pivotal role in poultry production by providing high-quality semen. Typically, fertility peaks between 30 and 40 weeks of age and then declines rapidly from 45 to 55 weeks of age. Research into improving fertility in aging roosters is essential to extend their productive life. While progress has been made, enhancing fertility in aging roosters remains a significant challenge. To identify the genes related to promoting sperm remodeling in aged Houdan roosters, we combined changes in testis and semen quality with transcriptome sequencing (RNA-seq) to analyze the synchrony of semen quality and testis development. In this study, 350-day-old Houdan breeder roosters were selected for RNA-seq analysis in testis tissues from induced molting roosters (D group) and non-induced molting roosters (47DG group). All analyses of differentially expressed genes (DEGs) and functional enrichment were performed. Finally, we selected six DEGs to verify the accuracy of the sequencing by qPCR. Compared with the 47DG group, sperm motility (P 
ISSN:1471-2164
1471-2164
DOI:10.1186/s12864-024-10544-3