Dihydroartemisinin-piperaquine effectiveness for seasonal malaria chemoprevention in settings with extended seasonal malaria transmission in Tanzania

Effectiveness of dihydroartemisinin-piperaquine (DP) as seasonal malaria chemoprevention (SMC) was assessed in Nanyumbu and Masasi Districts. Between March and June 2021, children aged 3–59 months were enrolled in a cluster randomized study. Children in the intervention clusters received a monthly,...

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Bibliographic Details
Published in:Scientific reports 2024-01, Vol.14 (1), p.2143-11, Article 2143
Main Authors: Mwaiswelo, Richard, Ngasala, Billy, Chaky, Frank, Molteni, Fabrizio, Mohamed, Ally, Lazaro, Samwel, Samwel, Bushukatale, Mmbando, Bruno P.
Format: Article
Language:English
Subjects:
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692/700
Antimalarials - therapeutic use
Artemisinins
Chemoprevention
Child, Preschool
Dihydroartemisinin
Disease transmission
Drug Combinations
Humanities and Social Sciences
Humans
Infant
Intervention
Malaria
Malaria - drug therapy
Malaria - epidemiology
Malaria - prevention & control
multidisciplinary
NCT
NCT05874869
Piperazines
Quinolines - therapeutic use
Science
Science (multidisciplinary)
Seasons
Tanzania - epidemiology
Vector-borne diseases
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Summary:Effectiveness of dihydroartemisinin-piperaquine (DP) as seasonal malaria chemoprevention (SMC) was assessed in Nanyumbu and Masasi Districts. Between March and June 2021, children aged 3–59 months were enrolled in a cluster randomized study. Children in the intervention clusters received a monthly, 3-days course of DP for three consecutive months regardless of malaria infection status, and those in the control clusters received no intervention. Malaria infection was assessed at before the first-round and at 7 weeks after the third-round of DP in both arms. Malaria prevalence after the third-round of DP administration was the primary outcome. Chi -square tests and logistic regression model were used to compare proportions and adjust for explanatory variables. Before the intervention, malaria prevalence was 13.7% (161/1171) and 18.2% (212/1169) in the intervention and control clusters, respectively, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-52706-z