Immunological and parasitological parameters after treatment with dexamethasone in murine Schistosoma mansoni

This work aimed to evaluate the effect of diphenyl dimethyl bicarboxylate (DDB) and dexamethasone alone and in combination with praziquantel on various parasitological, immunological and pathological parameters reflecting disease severity and morbidity in murine schistosomiasis. DDB and dexamethason...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 2010-09, Vol.105 (6), p.729-735
Main Authors: Aly, Ibrahim R B, Hendawy, Mohamed A, Ali, Eman, Hassan, Eman, Nosseir, Mona M F
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - therapeutic use
Animals
Anthelmintics - administration & dosage
Anthelmintics - therapeutic use
cytokines
Cytokines - blood
Cytokines - immunology
Dexamethasone - administration & dosage
Dexamethasone - therapeutic use
Dioxoles - administration & dosage
Dioxoles - therapeutic use
Drug Therapy, Combination - methods
Glucocorticoids - administration & dosage
Glucocorticoids - therapeutic use
Granuloma - parasitology
Granuloma - pathology
Liver - parasitology
Liver - pathology
Male
Mice
morbidity
PARASITOLOGY
Praziquantel - administration & dosage
Praziquantel - therapeutic use
Schistosoma mansoni
schistosomiasis
Schistosomiasis mansoni - drug therapy
Schistosomiasis mansoni - immunology
Schistosomiasis mansoni - parasitology
Schistosomiasis mansoni - pathology
Severity of Illness Index
treatment
TROPICAL MEDICINE
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Summary:This work aimed to evaluate the effect of diphenyl dimethyl bicarboxylate (DDB) and dexamethasone alone and in combination with praziquantel on various parasitological, immunological and pathological parameters reflecting disease severity and morbidity in murine schistosomiasis. DDB and dexamethasone had no effect on worm burden but altered tissue egg distribution. This indicates that, under the schedule used, neither drug interfered with the development of adult worms or oviposition, but both can modulate liver pathology. Dexamethasone resulted in a greater reduction in granuloma size than did DDB. Dexamethasone-treated mice also showed lower levels of serum gamma interferon (IFN-γ), interleukin-12 (IL-12) and IL-4, together with higher IL-10 levels, than infected untreated control animals. These data suggest that dexamethasone is a convenient and promising coadjuvant agent that results in decreased morbidity in murine schistosomiasis.
ISSN:0074-0276
1678-8060
1678-8060
0074-0276
DOI:10.1590/S0074-02762010000600001