Electro-oxidative quinylation of sulfides to sulfur ylides in batch and continuous flow

An unprecedented strategy for preparing a series of sulfur ylides through electro-oxidative quinylation of sulfides in batch and continuous flow has been developed. Good to excellent yields were obtained with excellent functional group compatibility and good concentration tolerance under exogenous o...

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Bibliographic Details
Published in:iScience 2024-01, Vol.27 (1), p.108605-108605, Article 108605
Main Authors: Huang, Xiangxing, Yao, Yifei, Yin, Xing, Guan, Wenjing, Yuan, Chengcheng, Fang, Zheng, Qin, Hong, Liu, Chengkou, Guo, Kai
Format: Article
Language:English
Subjects:
Chemistry
Continuum mechanics
Electrochemistry
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Summary:An unprecedented strategy for preparing a series of sulfur ylides through electro-oxidative quinylation of sulfides in batch and continuous flow has been developed. Good to excellent yields were obtained with excellent functional group compatibility and good concentration tolerance under exogenous oxidant- and transition metal-free conditions. Advantageously, this electrosynthesis methodology was scalable with higher daily production and steady production was achieved attributing to the use of micro-flow cells. [Display omitted] •The preparation of sulfur ylides through electro-oxidative quinylation of sulfides•Exogenous oxidant and transition metal-free electrolysis conditions•Excellent functional group compatibility and good concentration tolerance•Good scalable potential, higher and steady production using micro-flow cells Chemistry; Continuum mechanics; Electrochemistry
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2023.108605