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Activation of macrophage mediated host defense against Salmonella typhimurium by Morus alba L
The innate immune system plays a crucial role in the initiation and subsequent direction of adaptive immune responses, as well as in the removal of pathogens that have been targeted by an adaptive immune response. L. was reported to have immunostimulatory properties that might protect against infect...
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| Published in: | Food & nutrition research 2018-02, Vol.62, p.1-10 |
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| cites | cdi_FETCH-LOGICAL-c357t-a10ecbf99ea4f82a9f5f7c51ab427d5b9d82224f598086e5cc5f8f3bccaa8ea93 |
| container_end_page | 10 |
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| container_title | Food & nutrition research |
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| creator | Chang, BoYoon Koo, BongSeong Lee, HyeonCheol Oh, Joa Sub Kim, SungYeon |
| description | The innate immune system plays a crucial role in the initiation and subsequent direction of adaptive immune responses, as well as in the removal of pathogens that have been targeted by an adaptive immune response.
L. was reported to have immunostimulatory properties that might protect against infectious diseases. However, this possibility has not yet been explored. The present study investigated the protective and immune-enhancing ability of
L. against infectious disease and the mechanisms involved.
To investigate the immune-enhancing effects of
L., we used a bacterial infection model.
The lifespan of mice infected with a lethal dose of
(1 × 10
colony forming units - CFU) was significantly extended when they were administered
L. Furthermore,
L. activated macrophages, monocytes, and neutrophils and induced Th1 cytokines (IL-12, IFN-γ, TNF-α) in mice infected with a sublethal dose (1 × 10
CFU) of
.
L. significantly stimulated the uptake of bacteria into peritoneal macrophages as indicated by increased phagocytosis. Peritoneal macrophages derived from C3H/HeJ mice significantly inhibited
L. induced NO production and TNF-α secretion compared with peritoneal macrophages derived from C3H/HeN mice.
These results suggest that the innate immune activity of
L. against bacterial infection in mice occurs through activation of the TLR4 signaling pathway. |
| doi_str_mv | 10.29219/fnr.v62.1289 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_f59b41ef243c4d15afe888d9eb7b34c6</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_f59b41ef243c4d15afe888d9eb7b34c6</doaj_id><sourcerecordid>2116802737</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-a10ecbf99ea4f82a9f5f7c51ab427d5b9d82224f598086e5cc5f8f3bccaa8ea93</originalsourceid><addsrcrecordid>eNpdkkuLFDEURgtRnIcu3UrAjZtu865kIwyDjgMtLlRwI-EmlXSnqaq0SVVD_3vT0-Mw4yqvw-Hm3q9p3hC8pJoS_SGMebmXdEmo0s-acyIFX0hJfj1_tD9rLkrZYiwZVvxlc0a14KJl8rz5feWmuIcpphGlgAZwOe02sPZo8F2EyXdok8qEOh_8WDyCNcSxnr9DP6TR9z2g6bDbxGHOcR6QPaCvKc8FQW8BrV41LwL0xb--Xy-bn58__bj-slh9u7m9vlotHBPttACCvbNBaw88KAo6iNA6QcBy2nbC6k5RSnkQWmElvXBOBBWYdQ5AedDssrk9ebsEW7PLcYB8MAmiubtIeW0gT9H13lSJ5cQHypnjHREQvFKq0962lnEnq-vjybWbbe2B8-OUoX8iffoyxo1Zp70RikuKj8W8vxfk9Gf2ZTJDLO7YqtGnuRiKCddcEaYq-u4_dJvmPNZWGUqIVJi2rK3U4kTV2ZSSfXgohmBzFwJTQ2BqCMwxBJV_-_gHD_S_qbO_nk6wnQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2116802737</pqid></control><display><type>article</type><title>Activation of macrophage mediated host defense against Salmonella typhimurium by Morus alba L</title><source>PubMed Central (Open access)</source><source>SPORTDiscus with Full Text</source><creator>Chang, BoYoon ; Koo, BongSeong ; Lee, HyeonCheol ; Oh, Joa Sub ; Kim, SungYeon</creator><creatorcontrib>Chang, BoYoon ; Koo, BongSeong ; Lee, HyeonCheol ; Oh, Joa Sub ; Kim, SungYeon</creatorcontrib><description>The innate immune system plays a crucial role in the initiation and subsequent direction of adaptive immune responses, as well as in the removal of pathogens that have been targeted by an adaptive immune response.
L. was reported to have immunostimulatory properties that might protect against infectious diseases. However, this possibility has not yet been explored. The present study investigated the protective and immune-enhancing ability of
L. against infectious disease and the mechanisms involved.
To investigate the immune-enhancing effects of
L., we used a bacterial infection model.
The lifespan of mice infected with a lethal dose of
(1 × 10
colony forming units - CFU) was significantly extended when they were administered
L. Furthermore,
L. activated macrophages, monocytes, and neutrophils and induced Th1 cytokines (IL-12, IFN-γ, TNF-α) in mice infected with a sublethal dose (1 × 10
CFU) of
.
L. significantly stimulated the uptake of bacteria into peritoneal macrophages as indicated by increased phagocytosis. Peritoneal macrophages derived from C3H/HeJ mice significantly inhibited
L. induced NO production and TNF-α secretion compared with peritoneal macrophages derived from C3H/HeN mice.
These results suggest that the innate immune activity of
L. against bacterial infection in mice occurs through activation of the TLR4 signaling pathway.</description><identifier>ISSN: 1654-661X</identifier><identifier>EISSN: 1654-661X</identifier><identifier>DOI: 10.29219/fnr.v62.1289</identifier><identifier>PMID: 29545736</identifier><language>eng</language><publisher>Sweden: Swedish Nutrition Foundation, SNF</publisher><subject>Adaptive immunity ; Antibiotics ; Bacteria ; Bacterial infections ; Cell activation ; Cytokines ; Flavonoids ; immune defense ; Immune response ; Immune system ; Immunology ; Immunostimulation ; Infections ; Infectious diseases ; Innate immunity ; Interferon ; Interleukin 12 ; Lethal dose ; Leukocytes (neutrophilic) ; Life span ; Lymphocytes T ; macrophage ; Macrophages ; Mice ; Monocytes ; Morus alba ; Morus alba L ; Original ; Penicillin ; Peritoneum ; Phagocytosis ; Rodents ; Salmonella ; Salmonella Typhimurium ; Signal transduction ; Sublethal dosage ; TLR4 ; TLR4 protein ; Toll-like receptors ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>Food & nutrition research, 2018-02, Vol.62, p.1-10</ispartof><rights>2018. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 BoYoon Chang et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-a10ecbf99ea4f82a9f5f7c51ab427d5b9d82224f598086e5cc5f8f3bccaa8ea93</citedby><cites>FETCH-LOGICAL-c357t-a10ecbf99ea4f82a9f5f7c51ab427d5b9d82224f598086e5cc5f8f3bccaa8ea93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846209/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846209/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29545736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, BoYoon</creatorcontrib><creatorcontrib>Koo, BongSeong</creatorcontrib><creatorcontrib>Lee, HyeonCheol</creatorcontrib><creatorcontrib>Oh, Joa Sub</creatorcontrib><creatorcontrib>Kim, SungYeon</creatorcontrib><title>Activation of macrophage mediated host defense against Salmonella typhimurium by Morus alba L</title><title>Food & nutrition research</title><addtitle>Food Nutr Res</addtitle><description>The innate immune system plays a crucial role in the initiation and subsequent direction of adaptive immune responses, as well as in the removal of pathogens that have been targeted by an adaptive immune response.
L. was reported to have immunostimulatory properties that might protect against infectious diseases. However, this possibility has not yet been explored. The present study investigated the protective and immune-enhancing ability of
L. against infectious disease and the mechanisms involved.
To investigate the immune-enhancing effects of
L., we used a bacterial infection model.
The lifespan of mice infected with a lethal dose of
(1 × 10
colony forming units - CFU) was significantly extended when they were administered
L. Furthermore,
L. activated macrophages, monocytes, and neutrophils and induced Th1 cytokines (IL-12, IFN-γ, TNF-α) in mice infected with a sublethal dose (1 × 10
CFU) of
.
L. significantly stimulated the uptake of bacteria into peritoneal macrophages as indicated by increased phagocytosis. Peritoneal macrophages derived from C3H/HeJ mice significantly inhibited
L. induced NO production and TNF-α secretion compared with peritoneal macrophages derived from C3H/HeN mice.
These results suggest that the innate immune activity of
L. against bacterial infection in mice occurs through activation of the TLR4 signaling pathway.</description><subject>Adaptive immunity</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>Cell activation</subject><subject>Cytokines</subject><subject>Flavonoids</subject><subject>immune defense</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Immunostimulation</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Innate immunity</subject><subject>Interferon</subject><subject>Interleukin 12</subject><subject>Lethal dose</subject><subject>Leukocytes (neutrophilic)</subject><subject>Life span</subject><subject>Lymphocytes T</subject><subject>macrophage</subject><subject>Macrophages</subject><subject>Mice</subject><subject>Monocytes</subject><subject>Morus alba</subject><subject>Morus alba L</subject><subject>Original</subject><subject>Penicillin</subject><subject>Peritoneum</subject><subject>Phagocytosis</subject><subject>Rodents</subject><subject>Salmonella</subject><subject>Salmonella Typhimurium</subject><subject>Signal transduction</subject><subject>Sublethal dosage</subject><subject>TLR4</subject><subject>TLR4 protein</subject><subject>Toll-like receptors</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis 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SungYeon</creator><general>Swedish Nutrition Foundation, SNF</general><general>Open Academia</general><general>Swedish Nutrition 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alba L</title><author>Chang, BoYoon ; Koo, BongSeong ; Lee, HyeonCheol ; Oh, Joa Sub ; Kim, SungYeon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-a10ecbf99ea4f82a9f5f7c51ab427d5b9d82224f598086e5cc5f8f3bccaa8ea93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adaptive immunity</topic><topic>Antibiotics</topic><topic>Bacteria</topic><topic>Bacterial infections</topic><topic>Cell activation</topic><topic>Cytokines</topic><topic>Flavonoids</topic><topic>immune defense</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Immunostimulation</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Innate immunity</topic><topic>Interferon</topic><topic>Interleukin 12</topic><topic>Lethal dose</topic><topic>Leukocytes (neutrophilic)</topic><topic>Life span</topic><topic>Lymphocytes T</topic><topic>macrophage</topic><topic>Macrophages</topic><topic>Mice</topic><topic>Monocytes</topic><topic>Morus alba</topic><topic>Morus alba L</topic><topic>Original</topic><topic>Penicillin</topic><topic>Peritoneum</topic><topic>Phagocytosis</topic><topic>Rodents</topic><topic>Salmonella</topic><topic>Salmonella Typhimurium</topic><topic>Signal transduction</topic><topic>Sublethal dosage</topic><topic>TLR4</topic><topic>TLR4 protein</topic><topic>Toll-like receptors</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, BoYoon</creatorcontrib><creatorcontrib>Koo, BongSeong</creatorcontrib><creatorcontrib>Lee, HyeonCheol</creatorcontrib><creatorcontrib>Oh, Joa Sub</creatorcontrib><creatorcontrib>Kim, SungYeon</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium 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(PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Food & nutrition research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, BoYoon</au><au>Koo, BongSeong</au><au>Lee, HyeonCheol</au><au>Oh, Joa Sub</au><au>Kim, SungYeon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of macrophage mediated host defense against Salmonella typhimurium by Morus alba L</atitle><jtitle>Food & nutrition research</jtitle><addtitle>Food Nutr Res</addtitle><date>2018-02-21</date><risdate>2018</risdate><volume>62</volume><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1654-661X</issn><eissn>1654-661X</eissn><abstract>The innate immune system plays a crucial role in the initiation and subsequent direction of adaptive immune responses, as well as in the removal of pathogens that have been targeted by an adaptive immune response.
L. was reported to have immunostimulatory properties that might protect against infectious diseases. However, this possibility has not yet been explored. The present study investigated the protective and immune-enhancing ability of
L. against infectious disease and the mechanisms involved.
To investigate the immune-enhancing effects of
L., we used a bacterial infection model.
The lifespan of mice infected with a lethal dose of
(1 × 10
colony forming units - CFU) was significantly extended when they were administered
L. Furthermore,
L. activated macrophages, monocytes, and neutrophils and induced Th1 cytokines (IL-12, IFN-γ, TNF-α) in mice infected with a sublethal dose (1 × 10
CFU) of
.
L. significantly stimulated the uptake of bacteria into peritoneal macrophages as indicated by increased phagocytosis. Peritoneal macrophages derived from C3H/HeJ mice significantly inhibited
L. induced NO production and TNF-α secretion compared with peritoneal macrophages derived from C3H/HeN mice.
These results suggest that the innate immune activity of
L. against bacterial infection in mice occurs through activation of the TLR4 signaling pathway.</abstract><cop>Sweden</cop><pub>Swedish Nutrition Foundation, SNF</pub><pmid>29545736</pmid><doi>10.29219/fnr.v62.1289</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Food & nutrition research, 2018-02, Vol.62, p.1-10 |
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| language | eng |
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| source | PubMed Central (Open access); SPORTDiscus with Full Text |
| subjects | Adaptive immunity Antibiotics Bacteria Bacterial infections Cell activation Cytokines Flavonoids immune defense Immune response Immune system Immunology Immunostimulation Infections Infectious diseases Innate immunity Interferon Interleukin 12 Lethal dose Leukocytes (neutrophilic) Life span Lymphocytes T macrophage Macrophages Mice Monocytes Morus alba Morus alba L Original Penicillin Peritoneum Phagocytosis Rodents Salmonella Salmonella Typhimurium Signal transduction Sublethal dosage TLR4 TLR4 protein Toll-like receptors Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | Activation of macrophage mediated host defense against Salmonella typhimurium by Morus alba L |
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